Nephrolithiasis and risk of hypertension in women
Nephrolithiasis and risk of hypertension in women
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DOI：
10.1016/s0272-6386(98)70136-2
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发表时间：
1998-11-01
影响因子：
13.2
通讯作者：
Curhan, GC
中科院分区：
文献类型：
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作者：
Madore, F;Stampfer, MJ;Curhan, GC
对男性的横断面和前瞻性研究表明肾结石和高血压之间存在正相关。然而，这种关联在女性中仍然存在争议。我们在护士健康研究中进行了一项关于肾结石与高血压风险之间关系的前瞻性研究，该研究于1980年纳入了89，376名年龄在34至59岁之间的女性。通过两年一次的邮寄问卷调查获得肾结石史、医生诊断的高血压和其他相关暴露的信息。2，558名女性（2.9%）报告了1980年之前的肾结石病史，11，883名女性（13.3%）报告了高血压病史。在1980年以前没有高血压的妇女中，12,540名妇女在1980年至1992年期间报告了新的高血压诊断，随访711,039人年。与无肾结石病史的女性相比，有肾结石病史的女性发生高血压的年龄校正相对危险度（RR）为1.36（95%可信区间[CI]，1.20 ~ 1.43）。在进一步调整体重指数（BMI）和钙、钠、钾、镁、咖啡因和酒精摄入量后，RR仅略有减弱（RR = 1.24; 95%CI，1.13至1.37）。相比之下，基线时有高血压的女性与无高血压的女性相比，随访期间肾结石事件的发生率相似（调整后的比值比[OR] = 1.01; 95%CI，0.85 - 1.20）。这些数据与在男性中获得的结果一致，并支持肾结石史与随后高血压风险增加相关的假设。饮食因素，如钙、钠和钾的摄入量，不能解释这种联系。肾结石和高血压共同的未确定的致病机制可能是这两种疾病发展的原因。(C)1998年由国家肾脏基金会，公司。
Cross-sectional and prospective studies of men suggest a positive association between nephrolithiasis and hypertension. However, this association remains controversial in women. We conducted a prospective study of the relation between nephrolithiasis and the risk for hypertension in the Nurses' Health Study, a cohort of 89,376 women aged 34 to 59 years in 1980. Information on the history of nephrolithiasis, physician-diagnosed hypertension, and other relevant exposures was obtained by biennial mailed questionnaire. A history of nephrolithiasis before 1980 was reported by 2,558 women (2.9%), and a history of hypertension was reported by 11,883 women (13.3%). Among women without hypertension before 1980, 12,540 women reported a new diagnosis of hypertension between 1980 and 1992, during 711,039 person-years of follow-up. Compared with those without a history of nephrolithiasis, the age-adjusted relative risk (RR) for incident hypertension in women with such a history was 1.36 (95% confidence interval [CI], 1.20 to 1.43). After further adjustment for body mass index (BMI) and the intake of calcium, sodium, potassium, magnesium, caffeine, and alcohol, the RR was only slightly attenuated (RR = 1.24; 95% CI, 1.13 to 1.37). In contrast, the occurrence of incident nephrolithiasis during follow-up was similar in women with hypertension at baseline compared with women without (adjusted odds ratio [OR] = 1.01; 95% CI, 0.85 to 1.20). These data are consistent with the results obtained in men and support the hypothesis that a history of nephrolithiasis is associated with an increased risk for subsequent hypertension. Dietary factors, such as the intake of calcium, sodium, and potassium, do not explain this association. Unidentified pathogenic mechanisms common to nephrolithiasis and hypertension may be responsible for the development of both disorders. (C) 1998 by the National Kidney Foundation, Inc.