The benefit to waitlist patients in a national paired kidney exchange program: Exploring characteristics of chain end living donor transplants.
The benefit to waitlist patients in a national paired kidney exchange program: Exploring characteristics of chain end living donor transplants.
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DOI：
10.1111/ajt.16749
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Veale JL
中科院分区：
文献类型：
--
作者：
Osbun N;Thomas AG;Ronin M;Cooper M;Flechner SM;Segev DL;Veale JL
非定向肾脏捐赠者可以启动活的捐赠链，结束等待名单上的患者。我们比较了2008年2月至2020年9月期间国家肾脏登记处(NKR)的749例等待链式末端移植与来自NKR和移植受者科学登记处的其他移植。与其他NKR接受者相比，链式末端接受者更多地年龄更大(53岁比52岁)，黑人(32%比15%)，公共保险(71%比46%)，以及更长的透析时间(3.0年比1.0年)。链状末端受者和非NKR活体供者之间也有类似的差异。黑人患者接受链状末端肾脏的比率接近于已故供者肾脏的比率(32%对34%)。链端供者年龄较大(52岁比44岁)，肾小球滤过率(93岁比98毫升/分钟/1.73平方米)略低于其他NKR供者。与对照活体供者相比，链端受者移植失败的风险和死亡率较高(P<；0.001)，但与已故供者受者相比，移植物失败(P=0.03)和死亡率(P<；0.01)较低。在多中心网络中共享非定向捐赠者可能会改善受益于活体捐赠的等待名单患者的多样性。
Non-directed kidney donors can initiate living donor chains that end to patients on the waitlist. We compared 749 National Kidney Registry (NKR) waitlist chain end transplants to other transplants from the NKR and the Scientific Registry of Transplant Recipients between February 2008 and September 2020. Compared to other NKR recipients, chain end recipients were more often older (53 vs 52 years), black (32% vs. 15%), publicly insured (71% vs. 46%), and spent longer on dialysis (3.0 vs. 1.0 years). Similar differences were noted between chain end recipients and non-NKR living donor recipients. Black patients received chain end kidneys at a rate approaching that of deceased donor kidneys (32% vs. 34%). Chain end donors were older (52 vs 44 years) with slightly lower glomerular filtration rates (93 vs. 98 mL/min/1.73 m2) than other NKR donors. Chain end recipients had elevated risk of graft failure and mortality compared to control living donor recipients (both p<0.01), but lower graft failure (p=0.03) and mortality (p<0.001) compared to deceased donor recipients. Sharing non-directed donors among a multicenter network may improve the diversity of waitlist patients who benefit from living donation.
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影响因子：
8.8
作者：
Gore, J. L.;Danovitch, G. M.;Singer, J. S.
通讯作者：
Singer, J. S.
DOI：
10.1111/ajt.15046
发表时间：
2018-11
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Holscher CM;Jackson K;Thomas AG;Haugen CE;DiBrito SR;Covarrubias K;Gentry SE;Ronin M;Waterman AD;Massie AB;Garonzik Wang J;Segev DL
通讯作者：
Segev DL
影响因子：
39.2
作者：
Durand, Christine M.;Bowring, Mary G.;Segev, Dorry L.
通讯作者：
Segev, Dorry L.
影响因子：
8.8
作者：
Hart, A.;Smith, J. M.;Israni, A. K.
通讯作者：
Israni, A. K.
DOI：
10.2215/cjn.06660619
发表时间：
2020-02-07
影响因子：
9.8
作者：
Leeser, David B.;Thomas, Alvin G.;Flechner, Stuart M.
通讯作者：
Flechner, Stuart M.