Somatosensory abnormalities in knee OA.
Somatosensory abnormalities in knee OA.
复制标题
膝关节骨关节炎的体感异常。
DOI：
10.1093/rheumatology/ker343
复制
发表时间：
2012
期刊：
影响因子：
5.5
通讯作者：
P. Dieppe
中科院分区：
文献类型：
--
作者：
V. Wylde;S. Palmer;I. Learmonth;P. Dieppe
目的
本研究的目的是使用定量感觉测试（QST）来探讨晚期膝关节OA患者表现出的躯体感觉异常的范围和患病率。
方法
107例膝关节OA患者和50例年龄和性别匹配的健康受试者参加了1小时的QST会议。在膝关节内侧和无痛前臂上进行测试。使用von Frey细丝评估轻触阈值，使用数字压力痛觉计评估压力疼痛阈值，使用Thermotest MSA评估热感觉和疼痛阈值。使用Mann-Whitney U检验发现膝关节OA患者和健康参与者的中位阈值存在显着差异。z评分转换用于确定膝关节OA患者不同躯体感觉异常的患病率。
结果
测试确定70%的膝关节OA患者至少有一种体感异常。膝关节OA患者和健康受试者的中位阈值比较显示，患者在骨关节炎膝关节处存在局部热感觉和触觉感觉减退以及压力痛觉过敏。触觉感觉减退和压力痛觉过敏也存在于无痛前臂。最常见的躯体感觉异常是触觉感觉减退和压力痛觉过敏，在20%至34%的患者中很明显。
结论
本研究发现OA患者表现出一系列的躯体感觉异常，其中最常见的是触觉感觉减退和压力痛觉过敏。现在需要进一步的研究来确定这些躯体感觉异常的临床意义。
OBJECTIVE
The aim of this study was to use quantitative sensory testing (QST) to explore the range and prevalence of somatosensory abnormalities demonstrated by patients with advanced knee OA.
METHODS
One hundred and seven knee OA patients and 50 age- and sex-matched healthy participants attended a 1-h QST session. Testing was performed on the medial side of the knee and the pain-free forearm. Light-touch thresholds were assessed using von Frey filaments, pressure pain thresholds using a digital pressure algometer, and thermal sensation and pain thresholds using a Thermotest MSA. Significant differences in median threshold values from knee OA patients and healthy participants were identified using Mann-Whitney U-tests. The z-score transformations were used to determine the prevalence of the different somatosensory abnormalities in knee OA patients.
RESULTS
Testing identified 70% of knee OA patients as having at least one somatosensory abnormality. Comparison of median threshold values between knee OA patients and healthy participants revealed that patients had localized thermal and tactile hypoaesthesia and pressure hyperalgesia at the osteoarthritic knee. Tactile hypoaesthesia and pressure hyperalgesia were also present at the pain-free forearm. The most prevalent somatosensory abnormalities were tactile hypoaesthesia and pressure hyperalgesia, evident in between 20 and 34% of patients.
CONCLUSION
This study found that OA patients demonstrate an array of somatosensory abnormalities, of which the most prevalent were tactile hypoaesthesia and pressure hyperalgesia. Further research is now needed to establish the clinical implications of these somatosensory abnormalities.
影响因子：
4
作者：
Hendiani, JA;Westlund, KN;McNearney, T
通讯作者：
McNearney, T