Autophagy, a double-edged sword in hepatocarcinogenesis.
Autophagy, a double-edged sword in hepatocarcinogenesis.
复制标题
DOI：
10.1080/23723556.2015.1004968
复制
发表时间：
2015-10
影响因子：
2.1
通讯作者：
Ou JH
中科院分区：
文献类型：
--
作者：
Tian Y;Wang L;Ou JH
自噬对肝癌发生具有相反的影响，具体取决于它发生在肝癌发生之前还是发生之后。自噬通过抑制氧化应激和 DNA 损伤来防止肝癌发生。然而，一旦肝癌发生，它也会抑制细胞死亡和肿瘤抑制因子的表达，从而促进肿瘤进展。
Autophagy has opposite effects on hepatocarcinogenesis depending on whether it occurs before or after its onset. Autophagy prevents the initiation of hepatocarcinogenesis by suppressing oxidative stress and DNA damage. However, it also inhibits cell death and the expression of tumor suppressors to promote tumor progression once hepatocarcinogenesis has been initiated.