Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
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DOI：
10.1016/j.tibs.2015.11.012
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发表时间：
2016-03
影响因子：
13.8
通讯作者：
Tsuji Y
中科院分区：
文献类型：
--
作者：
Bogdan AR;Miyazawa M;Hashimoto K;Tsuji Y
铁是生命所必需的，但也会导致细胞死亡。因此，细胞进化出了一套强大的、严格调控的基因来维持铁稳态。先前对铁稳态的机制研究已经深入了解了铁在人类健康和疾病中的作用。我们重点介绍铁代谢的新调节因子，包括铁运输蛋白 [溶质载体家族 39，SLC39，也称为 ZRT/IRT 样蛋白，ZIP；和聚（rC）结合蛋白，PCBP]和货物受体（NCOA4），其对于铁蛋白结合铁的释放至关重要。我们还讨论了铁在细胞凋亡中的新作用，以及一种称为“铁死亡”的新型铁依赖性细胞死亡途径、人类病理中铁代谢的失调，以及铁螯合剂在癌症治疗中的使用。
Iron is necessary for life, but can also cause cell death. Accordingly, cells evolved a robust, tightly regulated suite of genes for maintaining iron homeostasis. Previous mechanistic studies on iron homeostasis have granted insight into the role of iron in human health and disease. We highlight new regulators of iron metabolism, including iron-trafficking proteins [solute carrier family 39, SLC39, also known as ZRT/IRT-like protein, ZIP; and poly-(rC)-binding protein, PCBP] and a cargo receptor (NCOA4) that is crucial for release of ferritin-bound iron. We also discuss emerging roles of iron in apoptosis and a novel iron-dependent cell death pathway termed ‘ferroptosis’, the dysregulation of iron metabolism in human pathologies, and the use of iron chelators in cancer therapy.