Salivary glands: novel target sites for gene therapeutics
Salivary glands: novel target sites for gene therapeutics
复制标题
DOI：
10.1016/j.molmed.2004.10.003
复制
发表时间：
2004-12-01
影响因子：
13.6
通讯作者：
Wang, JH
中科院分区：
文献类型：
--
作者：
Baum, BJ;Voutetakis, A;Wang, JH
指导治疗性蛋白质的局部或系统表达是基因转移技术的潜在重要临床应用。理论上，基于基因的治疗方法比蛋白质治疗方法具有许多优势。为此目的，在动物模型中对许多组织进行了评价，最常见的是肝脏和骨骼肌。基于临床前研究，我们认为，唾液腺是一个有价值的，但低估，靶组织的全身和上消化道基因治疗的应用。
Directing the local or systemic expression of therapeutic proteins is a potentially important clinical application of gene transfer technology. Gene-based therapeutics theoretically offer many advantages over protein therapeutics. Numerous tissues have been evaluated for this purpose in animal models, most commonly the liver and skeletal muscle. Based on pre-clinical studies, we suggest that salivary glands are a valuable, yet underappreciated, target tissue for both systemic and upper gastrointestinal tract gene therapeutic applications.