Novel Variants of Clade 2.3.4 Highly Pathogenic Avian Influenza A(H5N1) Viruses, China
Novel Variants of Clade 2.3.4 Highly Pathogenic Avian Influenza A(H5N1) Viruses, China
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DOI：
10.3201/eid1912.130340
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发表时间：
2013-12-01
影响因子：
11.8
通讯作者：
Liu, Xiufan
中科院分区：
文献类型：
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作者：
Gu, Min;Zhao, Guo;Liu, Xiufan
我们对2009-2012年从中国家禽中分离的7株高致病性H5 N1禽流感病毒进行了特征分析，发现它们属于进化枝2.3.4，但不属于3个定义的亚进化枝。H5 N1亚型变异体的抗原性漂移可能会降低为控制家禽中这些病毒而设计的疫苗的效力。
We characterized 7 highly pathogenic avian influenza A(H5N1) viruses isolated from poultry in China during 2009-2012 and found that they belong to clade 2.3.4 but do not fit within the 3 defined subclades. Antigenic drift in subtype H5N1 variants may reduce the efficacy of vaccines designed to control these viruses in poultry.