Proton Electrochemical Gradients and Active Transport: The Saga of lac Permease
Proton Electrochemical Gradients and Active Transport: The Saga of lac Permease
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质子电化学梯度和主动运输：紫胶渗透酶的传奇
DOI：
10.1111/j.1749-6632.1985.tb14879.x
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发表时间：
1985
影响因子：
5.2
通讯作者：
Kaback Hr
中科院分区：
文献类型：
--
作者：
Kaback Hr
就像DNA的双螺旋模型为分子遗传学提供了支柱一样，彼得·米切尔在20世纪60年代提出并完善的化学渗透假说现在是各种生物能现象的概念框架。在其最一般的形式（图1）中，化学渗透概念假定能量耦合膜中许多过程的直接驱动力是H+电化学梯度（A1 + A2），其由根据以下关系的电参数和化学参数组成：
In much the same way that the double helix model of DNA has provided the backbone for molecular genetics, the chemiosmotic hypothesis, formulated and refined by Peter Mitchell during the 1960~,’-~ is now the conceptual framework for a wide variety of bioenergetic phenomena. In its most general form (FIG. l), the chemiosmotic concept postulates that the immediate driving force for many processes in energy-coupling membranes is a H+ electrochemical gradient (Aj&+)‘composed of electrical and chemical parameters according to the following relationship: