SURVIVAL OF LACTOBACILLUS SPECIES (STRAIN GG) IN HUMAN GASTROINTESTINAL-TRACT
SURVIVAL OF LACTOBACILLUS SPECIES (STRAIN GG) IN HUMAN GASTROINTESTINAL-TRACT
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DOI：
10.1007/bf01308354
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发表时间：
1992-01-01
影响因子：
3.1
通讯作者：
SALMINEN, S
中科院分区：
文献类型：
--
作者：
GOLDIN, BR;GORBACH, SL;SALMINEN, S
一种新分离的人源乳杆菌GG （Lactobacillus GG）已被研究以确定其在人胃肠道中的生存能力。当76名志愿者被喂食为冷冻浓缩物或牛奶或乳清中的发酵制剂时，GG乳杆菌在所有接受发酵牛奶或乳清的受试者的粪便中被回收，86%接受冷冻浓缩物的受试者在培养单个粪便标本时被回收。同时接受氨苄西林治疗的患者的粪便中也存在该菌。在停止饲喂这种生物后，4天后87%的志愿者和7天后33%的受试者的粪便中仍然存在GG乳杆菌。乳酸菌GG降低了志愿者粪便细菌β -葡萄糖醛酸酶活性约80%。这些研究表明，GG乳杆菌可以在人胃肠道中存活并暂时定植，并可以影响常驻微生物群的代谢活性。
A newly isolated strain of a species of Lactobacillus of human origin, designated GG (Lactobacillus GG), has been studied to determine its ability to survive in the human gastrointestinal tract. When fed to 76 volunteers as a frozen concentrate or as a fermented preparation in milk or whey, Lactobacillus GG was recovered in the feces of all subjects receiving the fermented milk or whey and in 86% receiving the frozen concentrate when a single fecal specimen was cultured. The organism was also present in the feces of subjects concurrently receiving ampicillin. After terminating feeding of the organism, Lactobacillus GG persisted in the feces of 87% of volunteers four days later and in 33% of subjects seven days later. Lactobacillus GG lowered fecal bacterial beta-glucuronidase activity by approximately 80% in volunteers given the organism for four weeks. These studies demonstrate that Lactobacillus GG can survive and temporarily colonize the human gastrointestinal tract and can affect the metabolic activity of the resident microflora.