Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.
Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.
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DOI：
10.1016/j.jneuroim.2010.04.013
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发表时间：
2010-08-25
影响因子：
3.3
通讯作者：
Offner H
中科院分区：
文献类型：
--
作者：
Sinha S;Miller L;Subramanian S;McCarty OJ;Proctor T;Meza-Romero R;Huan J;Burrows GG;Vandenbark AA;Offner H
重组T细胞配体（RTLs）以抗原特异性方式改善实验性自身免疫性脑脊髓炎（EAE）。我们评估了RTL401 （I-As α1β1 + PLP-139-151）对EAE小鼠脾细胞的影响，以研究RTL- T细胞耐受诱导机制。RTLs通过RTL-MHC-α1β1片段与B、巨噬细胞和dc结合。RTL结合降低了脾脏巨噬细胞/DC上CD11b的表达，并且rtl401条件下的巨噬细胞/DC抑制T细胞活化，而不是B细胞。RTL培养的脾细胞转移EAE的能力降低可能是通过巨噬细胞/DC介导的，因为RTL治疗EAE不需要B细胞。这些结果证明了RTL结合APCs调控T细胞的新途径。
Recombinant T cell ligands (RTLs) ameliorate experimental autoimmune encephalomyelitis (EAE) in antigen specific manner. We evaluated effects of RTL401 (I-As α1β1 + PLP-139-151) on splenocytes from mice with EAE to study RTL- T cell-tolerance-inducing mechanisms. RTLs bound to B, macrophages and DCs, through RTL-MHC-α1β1 moiety. RTL binding reduced CD11b expression on splenic macrophages/DC, and RTL401-conditioned macrophages/DC, not B cells, inhibited T cell activation. Reduced ability of RTL- incubated splenocytes to transfer EAE was likely mediated through macrophages/DC, since B cells were unnecessary for RTL treatment of EAE. These results demonstrate novel pathway of T cell regulation by RTL bound APCs.
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影响因子：
5.3
作者：
Sinha, Sushmita;Subramanian, Sandhya;Offner, Halina
通讯作者：
Offner, Halina
影响因子：
6.2
作者：
Sinha, Sushmita;Subramanian, Sandhya;Emerson-Webber, Ashley;Lindner, Maren;Burrows, Gregory G.;Grafe, Marjorie;Linington, Christopher;Vandenbark, Arthur A.;Bernard, Claude C. A.;Offner, Halina
通讯作者：
Offner, Halina
影响因子：
4.4
作者：
Bullard, DC;Hu, XZ;Barnum, SR
通讯作者：
Barnum, SR
影响因子：
3.2
作者：
Nicholson, Grant C.;Tennant, Rachel C.;Hansel, Trevor T.
通讯作者：
Hansel, Trevor T.
影响因子：
8.6
作者：
Link, Jason M.;Rich, Cathleen M.;Vandenbark, Arthur A.
通讯作者：
Vandenbark, Arthur A.