Recruitment of HIV-1 target cells at topical mucosal sites: a sensitive and early marker for determining the safety of microbicide candidates.
Recruitment of HIV-1 target cells at topical mucosal sites: a sensitive and early marker for determining the safety of microbicide candidates.
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DOI：
10.1038/emi.2013.42
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发表时间：
2013-07
影响因子：
13.2
通讯作者：
Zhang, Xiaoyan
中科院分区：
文献类型：
--
作者：
Li, Liangzhu;Ben, Yinyin;Yuan, Songhua;Liu, Aiping;Wu, Huanmei;Xu, Jianqing;Zhang, Xiaoyan
To explore early biomarkers for establishing more sensitive safety evaluation assays in preclinical settings that determine the potential risks during the application of microbicide candidates, three representative microbicide candidates (cellulose sulphate, nonoxynol-9 and tenofovir), whose safety profiles have been well established in clinical trials, were included to gauge the sensitivities of different assays. Both mouse models and cell lines were employed to determine the sensitivities. The recruitment of immune cells at topical mucosal sites and the upregulation of HIV receptor/coreceptors in vitro were identified as highly sensitive biomarkers of the impact of microbicide candidates. Our data suggest that different evaluations/assays have their inherent sensitivities, and at least one assay from each sensitivity level should be included in the safety evaluation algorithm.
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影响因子：
4.9
作者：
Zhong, Maohua;He, Benxia;Yan, Huimin
通讯作者：
Yan, Huimin
影响因子：
3.6
作者：
Fichorova, RN;Bajpai, M;Doncel, GF
通讯作者：
Doncel, GF
DOI：
10.1126/science.1193748
发表时间：
2010-09-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
CAPRISA 004 Trial Group
影响因子：
1.5
作者：
Tao, Wang;Richards, Chris;Hamer, Dean
通讯作者：
Hamer, Dean
影响因子：
6.1
作者：
Li Liang-zhu;Yang Yu;Zhang Xiao-yan
通讯作者：
Zhang Xiao-yan