Longitudinal association between periodontal condition and glycaemic status in middle-aged adults: A cross-lagged panel analysis.
Longitudinal association between periodontal condition and glycaemic status in middle-aged adults: A cross-lagged panel analysis.
复制标题
中年成人牙周状况与血糖状态之间的纵向关联：交叉滞后面板分析。
作者：
Nasution D.L.I.;Furuta M.;Li H.;Zakaria M.N.;Takeshita T.;Peres M.A.;Yamashita;Y
AimTo调查牙周状况和牙周炎状态之间存在双向时间关系。Materials and MethodsThis纵向研究包括2198名参与者，平均年龄43.4 ± 7.7岁，在日本横滨进行牙科检查，在两个时间点，2003-2004年和2008-2009年，间隔5年。以牙周袋探诊深度（PPD）和临床附着水平（CAL）的平均值评估牙周病的情况。通过空腹血糖和糖化血红蛋白（HbA 1c）评估血糖状态。结果交叉滞后面板模型显示基线时HbA 1c对随访时平均PPD的影响（β= 0. 044，p = 0. 039）。空腹血糖对平均PPD的影响很小（β= 0.037，p = 0.059）。这是类似的空腹血糖或HbAlc对平均CAL. However，在相反的方向，平均PPD或CAL在基线空腹血糖或HbAlc在follow‐up.ConclusionsThis研究表明，一个单向的关系之间的血糖状态和牙周状况。然而，研究人群大多患有轻度牙周炎。牙周状况对重度牙周炎患者牙周炎状态的影响还有待进一步研究。
AimTo investigate the existence of a bidirectional temporal relationship between periodontal condition and glycaemic status.Materials and MethodsThis longitudinal study included 2198 participants with mean age 43.4 ± 7.7 years, who underwent dental examinations in Yokohama, Japan, at two time points, 2003–2004 and 2008–2009, at an interval of 5 years. Periodontal condition was assessed by the mean value of probing pocket depth (PPD) and clinical attachment level (CAL). Glycaemic status was assessed by fasting glucose and glycated haemoglobin (HbA1c).ResultsThe cross‐lagged panel models showed the effect of HbA1c at baseline on mean PPD at follow‐up (β= 0.044,p= .039). There was a marginal effect of fasting glucose on the mean PPD (β= 0.037,p= .059). It was similar to the effect of fasting glucose or HbAlc on mean CAL. However, in the opposite direction, no effect of mean PPD or CAL at baseline on fasting glucose or HbAlc at follow‐up was identified.ConclusionsThis study demonstrated a unidirectional relationship between glycaemic status and periodontal condition. The study population, however, had mostly mild periodontitis. Future studies are needed to investigate the effect of periodontal condition on glycaemic status in patients with severe periodontitis.