The evolution of HIV

The evolution of HIV
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艾滋病毒的演变

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发表时间:
1999
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影响因子:
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通讯作者:
K. Crandall
K. Crandall
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作者:
K. Crandall

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艾滋病毒的流行引发了传染病研究史上前所未有的科学努力。这一努力以前所未有的方式融合了临床研究、基础分子生物学、免疫学、细胞生物学、流行病学和数学生物学。在《艾滋病毒的进化》中,基思·A。克兰德尔汇集了来自这些学科的研究人员,提出了对艾滋病毒的分子生物学和分子进化的观点。这本书分为三个部分:“介绍艾滋病毒”探讨了病毒的分子生物学及其全球多样性的基本原理。“研究艾滋病毒多样性的分子方法”着眼于艾滋病毒的遗传学,模拟艾滋病毒序列的分子进化,使用系统发育推断来测试艾滋病毒传播假设,以及艾滋病毒群体遗传学的结合方法等主题。第三部分,“艾滋病毒进化的案例研究”通过纵向研究考察了宿主个体内部和之间的多样性水平,已知传播史的遗传学,以及艾滋病毒进化和疾病进展。这本书将有兴趣的研究人员和临床医生对艾滋病毒的工作,以及科学家研究分子进化,人口遗传学和进化生物学。作者是John M。作者:Coffin,基思A.放大图片作者:Joseph M.放大图片创作者:Brian Foley,Esther Guzman,Paul H.作者声明:大卫M.爱德华·希利斯作者:Holmes,Marcia L Kalish,Bette T. M.放大图片创作者:Julia A.作者:Gerald H.放大图片作者:托马斯.放大图片作者:McCutchan,Spencer V. Muse,奥利弗G. Pylons,艾伦G.放大图片作者:Richard W.艾伦·斯特凯蒂邓普顿放大图片作者:Stephen M.沃林斯基
The HIV epidemic has spawned a scientific effort unprecedented in the history of infectious disease research. This effort has merged aspects of clinical research, basic molecular biology, immunology, cell biology, epidemiology, and mathematical biology in ways that have not been seen before. In The Evolution of HIV Keith A. Crandall brings together researchers from these disciplines to present perspectives on both the molecular biology and molecular evolution of HIV. The book is organized into three sections: "Introduction to HIV" explores the fundamentals of the virus's molecular biology and its global diversity. "Molecular Methods for Studying HIV Diversity" looks at such topics as HIV phylogenetics, modeling the molecular evolution of HIV sequences, the use of phylogenetic inference to test an HIV transmission hypothesis, and coalescent approaches to HIV population genetics. The third section,"Case Studies of HIV Evolution" examines the levels of diversity within and among host individuals, the phylogenetics of known transmission histories, and HIV evolution and disease progression via longitudinal studies. The book will be of interest to researchers and clinicians working on HIV, as well as scientists studying molecular evolution, population genetics, and evolutionary biology. Contributors are John M. Coffin, Keith A. Crandall, Joseph Felsenstein, Walter M. Fitch, Brian Foley, Esther Guzman, Paul H. Harvey, David M. Hillis, Edward C. Holmes, Marcia L. Kalish, Bette T. M. Korber, Julia Krushkal, Carla L. Kuiken, Gerald H. Learn, Thomas Leitner, Wen-Hsiung Li, Francine E. McCutchan, Spencer V. Muse, Oliver G. Pylons, Allen G. Rodrigo, Raj Shankarappa, Richard W. Steketee, Alan R. Templeton, Donald M. Thea, Raphael P. Viscidi, Steven M. Wolinsky.