Humoral immunity in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis
Humoral immunity in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis
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DOI：
10.1385/ir:32:1-3:085
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发表时间：
2005-01-01
影响因子：
4.4
通讯作者：
Stark, JL
中科院分区：
文献类型：
--
作者：
Cross, AH;Stark, JL
中枢神经系统内免疫球蛋白合成异常是多发性硬化症 (MS) 患者的常见现象，常用于诊断。然而，目前尚不清楚抗体或产生抗体的 B 细胞和浆细胞是否对 MS 的发病机制至关重要。在这里，我们回顾了表明抗体在多发性硬化症发病机制中的作用的描述性数据。总结了 MS（实验性自身免疫性脑脊髓炎）动物模型中 B 细胞和抗体消耗研究的结果，以及使用嵌合单克隆抗体消耗 MS 患者 B 细胞的早期数据。
Abnormal immunoglobulin synthesis within the central nervous system is a common finding in patients with multiple sclerosis (MS) that is often used for diagnosis. However, it is not clear whether antibodies, or the B-cells and plasma cells that make them, are critical to the pathogenesis of MS. Here we review the descriptive data that suggest a role for antibody in the pathogenesis of MS. The results of B-cell and antibody depletion studies in the animal model for MS, experimental autoimmune encephalomyelitis, are summarized, as well as early data using a chimeric monoclonal antibody to deplete B-cells in patients with MS.