SYNTHESIS OF HEPATITIS-B SURFACE AND CORE ANTIGENS IN ESCHERICHIA-COLI
SYNTHESIS OF HEPATITIS-B SURFACE AND CORE ANTIGENS IN ESCHERICHIA-COLI
复制标题
DOI：
10.1038/291503a0
复制
发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
RUTTER, WJ
中科院分区：
文献类型：
--
作者：
EDMAN, JC;HALLEWELL, RA;RUTTER, WJ
构建了能在大肠杆菌中合成高水平乙型肝炎核心抗原和乙型肝炎表面抗原的重组质粒。抗原的表达受色氨酸操纵子调控区控制。重组DNA方法可能提供抗肝炎疫苗的来源。
Recombinant plasmids which direct the synthesis of high levels of hepatitis B core antigen and hepatitis B surface antigen in E. coli were constructed. The antigens were expressed under control of the tryptophan operon regulatory region. Recombinant DNA methods may provide a source of vaccine against hepatitis.