Heterogeneous Myeloid Cells in Tumors.
Heterogeneous Myeloid Cells in Tumors.
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DOI：
10.3390/cancers13153772
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发表时间：
2021-07-27
期刊：
影响因子：
5.2
通讯作者：
Fang J
中科院分区：
文献类型：
--
作者：
Dou A;Fang J
众所周知，淋巴细胞在肿瘤的免疫监视中起着关键作用。越来越多的证据表明，骨髓细胞对肿瘤的发展也有很大的影响。肿瘤相关髓系细胞（tumor-associated myeloid cells，TAMCs）是异质性的，对肿瘤细胞和肿瘤微环境（tumor microenvironment，TME）具有不同甚至相反的作用。此外，髓样细胞在调节淋巴细胞的行为中起关键作用，导致刺激或抑制肿瘤发展的免疫刺激性或免疫抑制性TME线索。根据髓系细胞在肿瘤中的功能，有促肿瘤和抗肿瘤髓系细胞。它们参与多效性过程，包括肿瘤细胞的生长、存活、分化、干性、侵袭、播散和转移、血管生成、TME的重塑、免疫调节和对癌症治疗的应答。了解TAMCs在肿瘤中的功能和机制将有助于发现新的治疗方法。越来越多的研究强调了骨髓细胞在癌症生物学和治疗中的关键作用。骨髓细胞是肿瘤微环境的主要组成部分。研究最多的肿瘤相关髓样细胞（TAMC）包括单核细胞、肿瘤相关巨噬细胞（TAM）、树突状细胞（DC）、癌症相关循环中性粒细胞、肿瘤相关中性粒细胞（TAN）和髓源性抑制细胞（MDSC）。这些异源性骨髓细胞具有促肿瘤或抗肿瘤的功能，对肿瘤发展的各个阶段，如肿瘤细胞的恶性克隆演变、生长、存活、侵袭、播散和转移，发挥复杂甚至相反的作用。TAMC还重塑TME和肿瘤脉管系统以有利于肿瘤发展。这些骨髓细胞的主要功能是调节淋巴细胞的行为，形成免疫刺激或免疫抑制TME线索。此外，TAMC在调节对癌症治疗的反应中起关键作用。靶向TAMCs作为单一疗法或与化疗或免疫疗法组合进行了大力测试。本文简要介绍了TAMC的亚群及其在肿瘤细胞、TME、血管生成、免疫调节和肿瘤治疗中的作用。
It is well known that lymphocytes play a key role in the immunosurveillance for tumors. Accumulating evidence indicates that myeloid cells also have a large impact on tumor development. The tumor-associated myeloid cells (TAMCs) are heterogeneous and exert distinct and even opposing effects on tumor cells and tumor microenvironment (TME). In addition, myeloid cells play a critical role in modulating the behavior of lymphocytes, resulting in immunostimulatory or immunosuppressive TME cues that stimulate or suppress tumor development. Based on the function of myeloid cells in tumors, there are pro-tumor and anti-tumor myeloid cells. They are involved in pleiotropic processes, including growth, survival, differentiation, stemness, invasiveness, dissemination and metastasis of tumor cells, angiogenesis, remodeling of TME, immunomodulation, and response to cancer therapy. Understanding the function and mechanism of TAMCs in tumors will shed light on uncovering novel therapy. Accumulating studies highlight a critical role of myeloid cells in cancer biology and therapy. The myeloid cells constitute the major components of tumor microenvironment (TME). The most studied tumor-associated myeloid cells (TAMCs) include monocytes, tumor-associated macrophages (TAMs), dendritic cells (DCs), cancer-related circulating neutrophils, tumor-associated neutrophils (TANs), and myeloid-derived suppressor cells (MDSCs). These heterogenous myeloid cells perform pro-tumor or anti-tumor function, exerting complex and even opposing effects on all stages of tumor development, such as malignant clonal evolution, growth, survival, invasiveness, dissemination and metastasis of tumor cells. TAMCs also reshape TME and tumor vasculature to favor tumor development. The main function of these myeloid cells is to modulate the behavior of lymphocytes, forming immunostimulatory or immunosuppressive TME cues. In addition, TAMCs play a critical role in modulating the response to cancer therapy. Targeting TAMCs is vigorously tested as monotherapy or in combination with chemotherapy or immunotherapy. This review briefly introduces the TAMC subpopulations and their function in tumor cells, TME, angiogenesis, immunomodulation, and cancer therapy.
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影响因子：
24.3
作者：
Correia, Ana Luisa;Bissell, Mina J.
通讯作者：
Bissell, Mina J.
DOI：
10.4049/jimmunol.0900582
发表时间：
2009-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castellaneta A;Sumpter TL;Chen L;Tokita D;Thomson AW
通讯作者：
Thomson AW
影响因子：
64.5
作者：
Binnewies, Mikhail;Mujal, Adriana M.;Krummel, Matthew F.
通讯作者：
Krummel, Matthew F.
DOI：
10.1084/jem.20151193
发表时间：
2016-10-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Afik R;Zigmond E;Vugman M;Klepfish M;Shimshoni E;Pasmanik-Chor M;Shenoy A;Bassat E;Halpern Z;Geiger T;Sagi I;Varol C
通讯作者：
Varol C
影响因子：
15.9
作者：
Cools-Lartigue, Jonathan;Spicer, Jonathan;Ferri, Lorenzo
通讯作者：
Ferri, Lorenzo