Infection frequency and profile in different age groups of kidney transplant recipients
Infection frequency and profile in different age groups of kidney transplant recipients
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DOI：
10.1097/01.tp.0000226068.66819.37
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发表时间：
2006-06-27
期刊：
影响因子：
6.2
通讯作者：
Abbott, Kevin C.
中科院分区：
文献类型：
--
作者：
Dharnidharka, Vikas R.;Caillard, Sophie;Abbott, Kevin C.
背景老年移植受者感染性死亡的风险高于年轻人，但迄今为止还没有研究关注儿童与成人的相对感染风险和感染特征差异，这可能彼此非常不同。根据美国肾脏数据系统（USRDS）的报告，分析了1991年至1998年期间主要医疗保险肾移植受者（n = 64，751）的数据，以获得移植后第一年内感染和感染类型的医疗保险索赔（包括住院和门诊）。采用考克斯回归模型对感染的校正风险比（AHR）进行建模。近年来，肾移植受者的感染总数显著增加。1995年或之后移植的患者与早期移植的患者相比，感染的校正风险显著更高（AHR 1.34，95%CI = 1.29 - 1.39）。与18-50岁的成年人和儿童相比，≥ 51岁的老年人感染率最高
Background. Older transplant recipients have been shown to be at greater risk for infectious death than younger adults, but no study to date has looked at relative risk of infection and infection profile differences for children versus adults, which may be very different from one another.Methods. Data from primary Medicare renal transplant recipients between 1991 and 1998 (n = 64,751), as reported in the United States Renal Data System (USRDS), were analyzed for Medicare claims (both inpatient and outpatient) for infection and type of infection in the first year posttransplant. Cox regression was used to model adjusted hazard ratios (AHR) for infection.Results. Total infections among renal transplant recipients increased significantly in more recent years. Patients transplanted in or after 1995 had a significantly higher adjusted risk for infection compared to those transplanted earlier (AHR 1.34, 95% CI = 1.29 -1.39). Older adults >= 51 years of age had the highest percentage of experiencing infection, as compared to adults between 18-50 years and children