TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation.
TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation.
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DOI：
10.1101/cshperspect.a022186
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发表时间：
2017-07-05
影响因子：
7.2
通讯作者：
Wrana JL
中科院分区：
文献类型：
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作者：
Mullen AC;Wrana JL
在发现转化生长因子-β (TGF-β) 后不久，脊椎动物和无脊椎动物模型中的开创性工作揭示了 TGF-β 家族是组织形态发生的核心调节因子。该家族的成员指导动物发育中一些最早的细胞命运决定，协调复杂的器官发生并有助于成人的组织稳态。在这里，我们重点关注 TGF-β 家族在哺乳动物干细胞生物学中的作用，并讨论其在多能性调节和细胞命运决定方面广泛而多样的活性。
Soon after the discovery of Transforming Growth Factor-beta (TGF-β), seminal work in vertebrate and invertebrate models revealed the TGF-β family to be central regulators of tissue morphogenesis. Members of the family direct some of the earliest cell fate decisions in animal development, coordinate complex organogenesis and contribute to tissue homeostasis in the adult. Here we focus on the role of the TGF-β family in mammalian stem cell biology and discuss its wide and varied activities both in the regulation of pluripotency and in cell fate commitment.