Sibling risks in cancer: clues to recessive or X-linked genes?
Sibling risks in cancer: clues to recessive or X-linked genes?
复制标题
DOI：
10.1054/bjoc.2000.1585
复制
发表时间：
2001-02-02
影响因子：
8.8
通讯作者：
Easton, D
中科院分区：
文献类型：
--
作者：
Hemminki, K;Vaittinen, P;Easton, D
根据瑞典全国家庭癌症数据库，对癌症病例的后代和兄弟姐妹的癌症风险进行了系统分析。对于检查的所有13个癌症部位，同一部位癌症病例的后代和兄弟姐妹的风险显着升高。兄弟姐妹患前列腺癌、睾丸癌、肾癌和膀胱癌的相对风险约为后代的2倍，这表明隐性或X连锁易感基因对这些癌症可能很重要。如果父母一方也受到影响，则其兄弟姐妹患结直肠癌、卵巢癌、前列腺癌和肾癌以及白血病的风险比人群发病率增加20倍以上，这与罕见的高风险易感等位基因的影响一致。(C)2001年癌症研究运动。
A systematic analysis of cancer risks to offspring and to siblings of cancer cases was carried out based on the nationwide Swedish Family-Cancer Database. For all 13 cancer sites examined, risks to both offspring and siblings of cases of cancer at the same site were significantly elevated. The relative risk to siblings was approximately 2 fold more than the offspring risk for cancers of the prostate, testis, kidney and bladder, suggesting that recessive or X-linked susceptibility genes may be important for these cancers. Risks to siblings of cases where a parent was also affected were increased >20 fold over population rates for colorectal, ovarian, prostate and renal cancer, and for leukaemia, consistent with the effects of rare high-risk susceptibility alleles. (C) 2001 Cancer Research Campaign.