Immune Interventions of Human Diseases through Toll-Like Receptors
Immune Interventions of Human Diseases through Toll-Like Receptors
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DOI：
10.1007/978-1-4419-1132-2_7
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Akira, Shizuo
中科院分区：
文献类型：
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作者：
Coban, Cevayir;Ishii, Ken J.;Akira, Shizuo
toll样受体（TLRs）是感染的免疫传感器，触发强大的先天免疫激活，随后是针对各种传染病的保护性适应性免疫。然而，最近的证据表明，tlr参与许多疾病的发病机制，不仅包括传染病，还包括自身免疫性疾病、过敏和动脉粥样硬化。因此，基于tlr的免疫干预的预防或治疗应用应该是有效的，但其安全性必须通过实验动物模型和人力资源来证明，包括单核苷酸多态性分析。在这里，我们重点介绍了tlr在人类疾病中的保护和致病作用的最新进展。
Toll-like receptors (TLRs) are the immune sensors for infections, triggering robust innate immune activation followed by protective adaptive immunity against various infectious diseases. Recent evidence, however, has suggested that TLRs are involved in the pathogenesis of many diseases, including not only infectious diseases but also autoimmune diseases, allergy and atherosclerosis. Therefore, prophylactic or therapeutic application of TLR-based immune interventions should be potent, but their safety must be demonstrated using experimental animal models as well as human resources, including analysis of single nucleotide polymorphisms. Here, we focus on recent advances in understanding of the protective and pathogenic roles of TLRs in human diseases.