Experience and the developing prefrontal cortex
Experience and the developing prefrontal cortex
复制标题
DOI：
10.1073/pnas.1121251109
复制
发表时间：
2012-10-16
影响因子：
11.1
通讯作者：
Gibb, Robbin
中科院分区：
文献类型：
--
作者：
Kolb, Bryan;Mychasiuk, Richelle;Gibb, Robbin
前额叶皮层（PFC）接收来自所有其他皮层区域的输入，并在时间上计划和指导运动，认知，情感和社会行为。它有一个长期的发展，允许通过经验获得复杂的认知能力，但使其容易受到可能导致功能异常的因素的影响，这通常表现为神经精神疾病。当前额叶皮质在发育过程中暴露于不同的环境事件时，例如感官刺激、压力、药物、激素和社交经历（包括父母和同伴的互动），发育中的前额叶皮质可能会以不同的方式发育。目前的审查的目标是说明如何开发PFC的电路可以塑造广泛的产前和产后因素。我们开始与前额叶功能和发展的概述，我们的结论与早期经验如何影响前额叶的发展和行为的考虑。
The prefrontal cortex (PFC) receives input from all other cortical regions and functions to plan and direct motor, cognitive, affective, and social behavior across time. It has a prolonged development, which allows the acquisition of complex cognitive abilities through experience but makes it susceptible to factors that can lead to abnormal functioning, which is often manifested in neuropsychiatric disorders. When the PFC is exposed to different environmental events during development, such as sensory stimuli, stress, drugs, hormones, and social experiences (including both parental and peer interactions), the developing PFC may develop in different ways. The goal of the current review is to illustrate how the circuitry of the developing PFC can be sculpted by a wide range of pre- and postnatal factors. We begin with an overview of prefrontal functioning and development, and we conclude with a consideration of how early experiences influence prefrontal development and behavior.