New Therapies for Lowering Triglyceride-Rich Lipoproteins: JACC Focus Seminar 3/4.
New Therapies for Lowering Triglyceride-Rich Lipoproteins: JACC Focus Seminar 3/4.
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DOI：
10.1016/j.jacc.2021.08.051
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发表时间：
2021-11-02
影响因子：
24
通讯作者：
Song, Wenliang
中科院分区：
文献类型：
--
作者：
Rosenson, Robert S.;Shaik, Aleesha;Song, Wenliang
关键词：
新的证据表明，来自肝脏和肠道的富含甘油三酯的脂蛋白残余物（TRL）浓度升高会增加动脉粥样硬化性心血管事件的风险。 Natural selection studies support a causal role for elevated concentrations of remnant cholesterol and the pathways contributing to perturbations in metabolic pathways regulating TRLs with an increased risk of atherosclerotic cardiovascular disease events.针对 TRL 代谢中特定催化途径的新疗法可减少实验模型中的动脉粥样硬化，并降低甘油三酯水平变化较大的患者中 TRL 的浓度。需要使用血管生成素样 3 蛋白和载脂蛋白 C-III 抑制剂进行临床试验，以进一步指导这些新兴疗法在残余胆固醇升高患者心血管风险管理范式中的潜在贡献。
Emerging evidence suggests that elevated concentrations of triglyceride-rich lipoprotein remnants (TRLs) derived from hepatic and intestinal sources contribute to the risk of atherosclerotic cardiovascular events. Natural selection studies support a causal role for elevated concentrations of remnant cholesterol and the pathways contributing to perturbations in metabolic pathways regulating TRLs with an increased risk of atherosclerotic cardiovascular disease events. New therapies targeting select catalytic pathways in TRL metabolism reduce atherosclerosis in experimental models, and concentrations of TRLs in patients with a vast range of triglyceride levels. Clinical trials with inhibitors of angiopoietin-like 3 protein and apolipoprotein C-III will be required to provide further guidance on the potential contribution of these emerging therapies in the paradigm of cardiovascular risk management in patients with elevated remnant cholesterol.
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影响因子：
8.1
作者：
Chi X;Britt EC;Shows HW;Hjelmaas AJ;Shetty SK;Cushing EM;Li W;Dou A;Zhang R;Davies BSJ
通讯作者：
Davies BSJ
影响因子：
39.3
作者：
Alexander, Veronica J.;Xia, Shuting;Tsimikas, Sotirios
通讯作者：
Tsimikas, Sotirios
影响因子：
24
作者：
Balling, Mie;Afzal, Shoaib;Nordestgaard, Borge G.
通讯作者：
Nordestgaard, Borge G.
影响因子：
6.5
作者：
Chen, Yan Q.;Pottanat, Thomas G.;Konrad, Robert J.
通讯作者：
Konrad, Robert J.
影响因子：
5.4
作者：
Ikezaki H;Lim E;Cupples LA;Liu CT;Asztalos BF;Schaefer EJ
通讯作者：
Schaefer EJ