An autopsy case of meningeal carcinomatosis with parenchymal invasion through the cranial and spinal nerve roots
An autopsy case of meningeal carcinomatosis with parenchymal invasion through the cranial and spinal nerve roots
复制标题
脑膜癌病尸检一例侵犯颅神经和脊神经根实质
DOI：
10.1111/neup.12127
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发表时间：
2014
期刊：
影响因子：
2.3
通讯作者：
Wakabayashi K
中科院分区：
文献类型：
--
作者：
Kon T;Funamizu Y;Miki Y;Tomiyama M;Baba M;Kurotaki H;Wakabayashi K
脑膜癌病是一种众所周知的恶性肿瘤并发症。我们报告一例22岁男性脑膜癌病，病程2个月，初始症状为头痛逐渐加重。尸检发现胃浸润腺癌。癌细胞呈弥漫性扩散至脑和脊髓蛛网膜下腔。在许多地方，蛛网膜下腔肿瘤细胞已浸润到颅神经和脊神经。此外，神经根中的癌细胞延伸到CNS-周围神经系统交界处以外的脑实质和脊髓。这些发现表明，脑和脊神经根可能是脑膜癌病侵犯脑实质的一个可能途径。
Meningeal carcinomatosis is a well‐known complication of malignant neoplasms. We report a case of meningeal carcinomatosis of 2 months' duration in a 22‐year‐old man, in whom the initial symptom was gradually worsening headache. Postmortem examination revealed infiltrating adenocarcinoma of the stomach. Carcinoma cells showed diffuse spread to the subarachnoid space of the brain and spinal cord. In many places, subarachnoid tumor cells had infiltrated to the cranial and spinal nerves. Moreover, carcinoma cells in the nerve roots extended to the parenchyma of the brain and spinal cord beyond the CNS‐peripheral nervous system junction. These findings suggest that cranial and spinal nerve roots can be a possible route of parenchymal invasion in meningeal carcinomatosis.