Effects of hepatic artery embolization with lipiodol and gelatin sponge particles on normal swine liver
Effects of hepatic artery embolization with lipiodol and gelatin sponge particles on normal swine liver
复制标题
碘油明胶海绵颗粒肝动脉栓塞对正常猪肝脏的影响
DOI：
10.1007/bf02603139
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发表时间：
1993
影响因子：
2.9
通讯作者：
J. Rosch
中科院分区：
文献类型：
--
作者：
Morio Sato;R. Yamada;B. Uchida;Penny Hedgepeth;J. Rosch
为了评价碘油（Lipiodol，Lp）和明胶海绵颗粒（Gelatin Sponge particles，GSP）肝动脉栓塞（Hepatic arterial embolization，HAE）对猪肝组织的影响，我们用GSP栓塞3头猪的肝动脉，Lp栓塞9头，Lp+GSP栓塞9头。在4周的实验期间，没有用GSP栓塞的猪自发死亡。1 ml/kg Lp组1头猪和2 ml/kg Lp组3头猪在2 h内死亡。用0.5 ml/kg Lp+GSP栓塞的两头猪第二天死亡。GSP组HAE前、HAE后即刻、HAE后1 h、HAE后4周的门静脉压（PVP）和肝静脉楔压（WHVP）值无明显变化。Lp> 0.2ml/kg组出现一过性显著升高。0.2 ml/kg Lp+GSP组和0.5 ml/kg Lp+GSP组的血糖持续升高。大体和组织学检查显示GSP和Lp组无肝损伤。HAE后4周，Lp+GSP组出现肝梗死、环状凝固性坏死伴假包膜和肝萎缩。用0.2ml/kg Lp+GSP和0.5ml/kg Lp+GSP栓塞的肝脏中，梗死、环状凝固性坏死和肝萎缩的发生率分别为67%、100%和75%。结论：用Lp+GSP栓塞肝动脉时，Lp用量应控制在0.1ml/kg以下。
In order to evaluate the effects of hepatic artery embolization (HAE) with Lipiodol (Lp) and gelatin sponge particles (GSP) on swine liver tissue, we embolized the hepatic arteries of 3 pigs with GSP, 9 with Lp, and 9 with Lp+GSP. None of the pigs embolized with GSP died spontaneously during the 4-week experimental period. One pig embolized with 1 ml/kg Lp and three pigs with 2 ml/kg Lp died within 2 h. Two pigs embolized with 0.5 ml/kg Lp+GSP died the following day. The portal vein pressure (PVP) and wedge hepatic vein pressure (WHVP) values before HAE, immediately after, 1 h after, and 4 weeks after HAE showed no remarkable change in the GSP group. Remarkable and temporary elevation was observed in the more than 0.2 ml/kg Lp group. Remarkable and continuous elevation was observed in the 0.2 ml/kg Lp+GSP and 0.5 ml/kg Lp+GSP groups. Gross and histological studies demonstrated no liver damage in the GSP and Lp group. Liver infarction, circular coagulation necrosis with pseudocapsule, and liver atrophy were found in the Lp+GSP group 4 weeks after HAE. The incidence of infarction, circular coagulation necrosis, and liver atrophy in the livers embolized with 0.2 ml/kg Lp+GSP and 0.5 ml/kg Lp+GSP were 67%, 100%, and 75%, respectively. In conclusion, when the hepatic artery is embolized with Lp+GSP, the volume of Lp should be limited to less than 0.1 ml/kg.