Fast rhythms in phrenic motoneuron and nerve discharges.
Fast rhythms in phrenic motoneuron and nerve discharges.
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膈运动神经元和神经放电的快节律。
DOI：
10.1152/jn.1991.66.3.674
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发表时间：
1991
影响因子：
2.5
通讯作者：
Shaw,CF
中科院分区：
文献类型：
--
作者：
Christakos,CN;Cohen,MI;Barnhardt,R;Shaw,CF
1. 用频谱分析和间隔分析方法研究了单个膈神经元放电的快节奏；并使用相干分析将它们与整个phr神经放电的相似节奏进行比较。本研究的目的是确定在PHR运动神经元和神经放电中表现为不同频谱峰的两种节律的起源：中频振荡（MFO，通常范围20-50 Hz）；高频振荡（HFO，通常范围50- 100hz）。2. 在人工通气瘫痪的猫中，对1)26个分离的单个PHR纤维（在8只戊巴比妥钠麻醉的猫中）和2)27个脊髓中识别的PHR运动神经元体（在5只失脑猫中）进行单位记录。同时从对侧PHR神经单相记录全PHR活动1例，从双侧PHR神经单相记录2例。3. 对这些信号进行了时域和频域分析。后者包括连贯性分析在人口同步性研究中的新应用。4. 所有PHR单元的自谱在神经MFO谱峰的频率范围内均出现明显的MFO峰，并出现谐波峰，表明各单元放电中存在这种快节奏。对不同吸气(I)期PHR活动增强的频谱分析表明，单位MFO和神经MFO的频率在吸气(I)期的过程中呈上升趋势。周期触发直方图和间隔分析表明，单位MFO的自谱峰频率与单位在吸气(I)期的峰值放电率非常接近。因此，单个MFO谱峰反映了运动神经元放电的节律性和增强性，相似的神经MFO谱峰反映了单个运动神经元放电的叠加性。5. 运动神经元的MFO与神经MFO的一致性较低或为零，表明在PHR运动神经元群中仅存在部分和微弱的MFO相关性。6. 在那些有清晰的PHR神经HFO光谱峰的猫（n = 11）中，从单位自谱和/或单位神经相干的HFO峰可以看出，记录的PHR运动神经元中约有一半有HFO。7. 对于具有HFO的运动神经元，单元和神经HFO之间的一致性是实质性的，特别是当后者很强时，表明许多PHR运动神经元之间存在HFO相关性。8. 根据从统一节奏的叠加产生聚合节奏的理论考虑，这些观察结果表明如下。（摘要删节为400字）
1. Fast rhythms in discharges of individual phrenic (PHR) motoneurons were studied by spectral and interval analyses; and they were compared, using coherence analysis, with similar rhythms in whole-PHR nerve discharge. The purpose of this study was to ascertain the origin of the two rhythms, manifested as distinct spectral peaks, in PHR motoneuron and nerve discharge: medium-frequency oscillations (MFO, usual range 20-50 Hz); and high-frequency oscillations (HFO, usual range 50-100 Hz). 2. In paralyzed artificially ventilated cats, unit recordings were taken from 1) 26 isolated single PHR fibers (in 8 sodium pentobarbital-anesthetized cats) and 2) 27 identified PHR motoneuron somata in the spinal cord (in 5 decerebrate cats). Simultaneous whole-PHR activity was monophasically recorded from the contralateral PHR nerve for 1 and from both PHR nerves for 2. 3. The signals were subjected to time- and frequency-domain analyses. The latter included a novel application of coherence analysis to the study of population synchrony. 4. The autospectra of all PHR units showed prominent MFO peaks in the frequency range of the nerve MFO spectral peaks, as well as harmonic peaks, indicating the presence of this type of fast rhythm in the units' discharges. Spectral analysis of the augmenting PHR activities in different segments of the inspiratory (I) phase showed that the frequency of unit MFO and of nerve MFO rose during the course of I. Further, cycle-triggered histogram and interval analysis indicated that the frequencies of unit MFO autospectral peaks were very close to the peak firing rates of the units during the portion of I analyzed. Thus unit MFO spectral peaks reflected the rhythmic and augmenting discharges of the motoneurons, and similar nerve MFO peaks reflected the superposition of individual motoneuron discharges. 5. The coherences of motoneurons' MFOs to nerve MFOs were low or zero, indicating that only partial and weak MFO correlations occurred within the PHR motoneuron population. 6. In those cats (n = 11) that had clear PHR nerve HFO spectral peaks, about one-half of the recorded PHR motoneurons had HFO, as indicated by HFO peaks in the unit autospectra and/or the unit-nerve coherences. 7. For motoneurons having HFO, the coherence between unit and nerve HFOs was substantial, particularly when the latter were strong, indicating HFO correlations among a number of PHR motoneurons. 8. In the light of theoretical considerations on the generation of aggregate rhythms from superposition of unitary rhythms, these observations indicate the following.(ABSTRACT TRUNCATED AT 400 WORDS)