Antifatigue and antiaging effects of Chinese rice wine in mice
Antifatigue and antiaging effects of Chinese rice wine in mice
复制标题
黄酒对小鼠的抗疲劳和抗衰老作用
DOI：
10.1002/fsn3.830
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发表时间：
2018-11-01
影响因子：
3.9
通讯作者：
Sun, Haiji
中科院分区：
文献类型：
--
作者：
Zhao, Pan;Wang, Jing;Sun, Haiji
黄酒（CRW）因其保健功效而广为人知，常用于中药方剂指导药物。本研究评估了 CRW 对小鼠模型抗疲劳和抗衰老活性的影响。将小鼠随机分为四组，连续 15 天使用 0.25 ml 蒸馏水、0.15、0.25 和 0.4 ml CRW。 CRW能明显提高肝糖原（LG）含量，降低血乳酸（BLA）和血尿素氮（BUN）水平，提高抗疲劳能力。在抗衰老实验中，CRW显着提高肝脏SOD活性、大脑皮层GSH-Px和CAT活性、身体质量、胸腺指数和脾指数，降低肝脏MDA水平、肝脏总胆固醇含量和海马AChE水平。 CRW 具有强大的抗疲劳能力，可以最大限度地减少与年龄相关的疾病的发生。
Chinese rice wine (CRW) is widely known for keeping good health and commonly used in the traditional Chinese medicine prescription guiding drug. This study assesses the effects of CRW on antifatigue and antiaging activities in mice models. Mice were randomly divided into four groups performing with 0.25 ml of distilled water, 0.15, 0.25, and 0.4 ml of CRW for 15 consecutive days. The CRW could obviously increase the content of liver glycogen (LG) and decrease the levels of blood lactic acid (BLA)and blood urea nitrogen (BUN) to improve antifatigue ability. In antiaging assay, CRW significantly increased the activity of SOD in liver, the activities of GSH-Px and CAT in brain cortex, body quality, thymus index, and spleen index, and decreased liver MDA levels, liver total cholesterol content, and AChE levels in hippocampus. The CRW has potent antifatigue ability and could minimize the occurrence of age-associated disorders.