An outbreak of Rift Valley fever among peri-urban dairy cattle in northern Tanzania, 2018
An outbreak of Rift Valley fever among peri-urban dairy cattle in northern Tanzania, 2018
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2018 年坦桑尼亚北部城郊奶牛爆发裂谷热
DOI：
10.1101/2021.09.15.459147
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
De Glanville W
中科院分区：
文献类型：
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作者：
De Glanville W
预计未发现的裂谷热(RVF)疫情将在流行国家爆发，但对其规模或频率知之甚少。我们描述了一次以前未报告的涉及奶牛的RVF疫情，该疫情似乎仅限于坦桑尼亚Moshi镇的边缘，发生于2018年5月至8月。这次暴发是使用在调查坦桑尼亚北部牲畜流产原因的队列研究中收集的样本进行回顾性检测的。使用血清学和定量逆转录聚合酶链式反应(RT-qPCR)相结合的方法，共鉴定了14例与裂谷热相关的牛流产。14例中有3例(21%)的乳样RT-qPCR也呈阳性。基因分型显示RVF病毒从两个谱系传播。在城市周边奶牛中发生裂谷热暴发，以及有证据表明裂谷热病毒在牛奶中脱落，突显了与城市和城市周边牲畜种群增长相关的新的人畜共患病风险的可能性。
Undetected Rift Valley fever (RVF) outbreaks are expected in endemic countries but little is known about their size or frequency. We describe a previously unreported RVF outbreak involving dairy cattle that appeared to be limited to the edge of the town of Moshi, Tanzania and occurred from May through August, 2018. The outbreak was detected retrospectively using samples collected as part of a cohort study investigating the causes of livestock abortion across northern Tanzania. A total of 14 RVF-associated cattle abortions were identified using a combination of serology and quantitative reverse transcription PCR (RT-qPCR). Milk samples from three (21%) of 14 cases were also RT-qPCR positive. Genotyping revealed circulation of RVF viruses from two lineages. The occurrence of an RVF outbreak among peri-urban dairy cattle, and evidence for RVF viral shedding in milk, highlights the potential for emerging zoonotic risks associated with the growth of urban and peri-urban livestock populations.