EVALUATION OF BONE TURNOVER IN TYPE-I OSTEOPOROSIS USING BIOCHEMICAL MARKERS SPECIFIC FOR BOTH BONE-FORMATION AND BONE-RESORPTION
EVALUATION OF BONE TURNOVER IN TYPE-I OSTEOPOROSIS USING BIOCHEMICAL MARKERS SPECIFIC FOR BOTH BONE-FORMATION AND BONE-RESORPTION
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DOI：
10.1007/bf01623829
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发表时间：
1993-09-01
影响因子：
4
通讯作者：
RUSSELL, RGG
中科院分区：
文献类型：
--
作者：
EASTELL, R;ROBINS, SP;RUSSELL, RGG
本研究的目的是评估I型骨质疏松症中骨转化的骨特异性生化标志物的使用，测试这种情况下骨转化异质性的证据，并试图通过使用骨形成和骨吸收的骨特异性生化标志物之间的关系来设计一个“解耦指数”。I型骨质疏松症女性（平均年龄64岁，SD 5; n = 63）血清骨钙素（骨形成的特定生化标志物）的平均水平为9.9 ng/ml (SD 2.0)，高于正常绝经后女性(平均年龄65岁，SD 6; n = 8.9 ng/ml (SD 2.0; p
The aims of the study were to evaluate the use of bone-specific biochemical markers of turnover in type I osteoporosis, to test for evidence of heterogeneity of bone turnover in this condition, and to attempt to devise an 'uncoupling index' by using the relationship between bone-specific biochemical markers of bone formation and bone resorption. In women with type I osteoporosis (mean age 64 years, SD 5; n = 63) the mean level of serum osteocalcin, a specific biochemical marker of bone formation, was 9.9 ng/ml (SD 2.0), which was higher than the level in normal postmenopausal women (mean age 65 years, SD 6; n = 8.9 ng/ml (SD 2.0; p