Embryonic karyotype of abortuses in relation to the number of previous miscarriages
Embryonic karyotype of abortuses in relation to the number of previous miscarriages
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DOI：
10.1016/s0015-0282(99)00495-1
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发表时间：
2000-02-01
影响因子：
6.7
通讯作者：
Suzumori, K
中科院分区：
文献类型：
--
作者：
Ogasawara, M;Aoki, K;Suzumori, K
目的：研究反复流产患者受孕产物中染色体异常的频率与既往流产次数的关系。设计：回顾性分析。地点：名古屋市立大学医学医院。患者：共有1，309名有2-20次连续妊娠早期流产史的妇女。干预措施：使用标准G-显带技术对受孕产品进行染色体分析。主要结果测量：研究了以前流产的每个数量的异常和正常胚胎核型的频率。研究既往流产者的妊娠结局，沿着既往流产者的染色体核型对后续流产的预测价值。结果：流产率随既往自然流产次数的增加而增加。随着流产次数的增加，异常胚胎核型的发生率显著降低，正常胚胎核型的发生率显著升高。71例胚胎染色体核型正常的患者中，44例随后流产，60例胚胎染色体核型异常的患者中，23例随后流产。与以前的正常胚胎核型的患者流产更频繁比那些异常kytotype. Conclusions（S）：正常胚胎核型的频率显着增加与以前的流产次数，和一个正常的核型在以前的怀孕是一个预测随后的流产。（Fertil Steril（R）2000;73：300-4. (C)2000年由美国生殖医学协会。
Objective: To examine the frequency of chromosomal abnormalities in products of conception from patients with recurrent miscarriages in relation to the number of previous miscarriages.Design: Retrospective analysis.Setting: Nagoya City University Medical Hospital.Patient(s): A total of 1,309 women with a history of 2-20 consecutive first-trimester abortions.Intervention(s): Chromosomal analysis performed on products of conception with use of a standard G-banding technique.Main Outcome Measure(s): The frequencies of abnormal and normal embryonic karyotypes for each number of previous abortions were studied. The subsequent pregnancy outcome of patients whose previous miscarriages were karyotyped were studied along with the predictive value of karyotyping of previous miscarriages for subsequent miscarriages.Result(s): The miscarriage rate increased with the number of previous spontaneous abortions. The frequency of abnormal embryonic karyotypes significantly decreased and that of normal embryonic karyotypes significantly increased with the number of previous abortions. Among 71 patients whose embryonic karyotypes were normal, 44 aborted subsequently, and 23 of 60 patients whose embryonic karyotypes were abnormal aborted subsequently. Patients with a previous normal embryonic karyotype aborted more frequently than those with an abnormal karyotype.Conclusion(s): The frequency of normal embryonic karyotypes significantly increases with the number of previous abortions, and a normal karyotype in a previous pregnancy is a predictor of subsequent miscarriage. (Fertil Steril(R) 2000;73:300-4. (C) 2000 by American Society for Reproductive Medicine.)