Stimulus-response characteristics of CO2-induced air hunger in normal
Stimulus-response characteristics of CO2-induced air hunger in normal
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DOI：
10.1016/0034-5687(95)00050-x
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发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Shea, SA
中科院分区：
文献类型：
--
作者：
Banzett, RB;Lansing, RW;Shea, SA
高碳酸血症引起一种不舒服的感觉，称为“空气饥饿”。我们研究了16名受试者在三种情况下PET（CO2）与空气饥饿强度等级的关系：1）固定频率和潮气量的高氧混合气体机械通气（两次静息通气），2）相同机械通气，但使用低氧气体混合物，3）高氧气体混合物自主呼吸。在每种情况下，PET（CO2）在几个水平之间随机变化，每个水平保持5 min。在高氧机械通气期间，空气饥饿感的平均阈值为43 Torr，即，高于静息PET（CO2）4 Torr; 50 Torr引起无法忍受的空气饥饿。PET（CO2）的阈值和耐受水平在个体之间存在差异，但与他们对CO2的反应没有很好的相关性。缺氧（PET（O2）60-75 Torr）使PET（CO2）在阈值和容差下仅下降2 Torr。呼吸大大减少了在任何给定PET（CO2）下经历的空气饥饿（阈值增加5 Torr，灵敏度降低50%）。
Hypercapnia evokes an uncomfortable sensation, termed 'air hunger'. We examined the relationship between PET(CO2) and ratings of air hunger intensity under three conditions in 16 subjects: 1) mechanical ventilation with hyperoxic gas mixtures at fixed frequency and tidal volume (twice resting ventilation), 2) the same mechanical ventilation, but with hypoxic gas mixture, 3) spontaneous breathing with hyperoxic gas mixture. In each case, PET(CO2) was varied randomly among several levels, each held for 5 min. During hyperoxic mechanical ventilation, the mean threshold for air hunger sensation was 43 Torr, i.e., 4 Torr above resting PET(CO2); intolerable air hunger was evoked by 50 Torr. The threshold and tolerable levels of PET(CO2) varied among individuals, but were not well correlated with their ventilatory responses to CO2. Hypoxia (PET(O2) 60-75 Torr) shifted the PET(CO2) at both threshold and tolerance down by only 2 Torr. Breathing greatly reduced the air hunger experienced at any given PET(CO2) (threshold increased 5 Torr, and sensitivity decreased 50%).