Negative Temperature Differential in Preterm Infants Less Than 29 Weeks Gestational Age: Associations With Infection and Maternal Smoking
Negative Temperature Differential in Preterm Infants Less Than 29 Weeks Gestational Age: Associations With Infection and Maternal Smoking
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DOI：
10.1097/nnr.0000000000000250
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发表时间：
2017-11-01
期刊：
影响因子：
2.5
通讯作者：
Tanaka, David T.
中科院分区：
文献类型：
--
作者：
Knobel-Dail, Robin B.;Sloane, Richard;Tanaka, David T.
低温与极早产儿发病率和死亡率的增加有关;持续的体温监测是必要的。体温调节是有限的早产儿Objectives.Objectives的研究的目的是评估和描述负温差（NTD），并评估NTD与婴儿人口统计学特征，病史和临床事件的关联。在22例胎龄小于29周的早产儿中，在出生后的前2周内每分钟测量腹部和足部温度。在所有研究日，所有婴儿的每日NTD范围为0 - 70.7%;所有婴儿的2周平均NTD范围为7.3%-38.5%。4例晚发型感染治疗的婴儿NTD高于18例未感染的婴儿（M = 27.8%，SD = 9.52 vs. M = 16.4%，SD = 5.34，p <0.05）。虽然没有统计学意义，但在早发性感染的婴儿中，NTD的平均百分比较高（24.1%对16.4%），非裔美国人（20.0%对15.3%），和/或母亲在怀孕期间吸烟（26.6% vs. 16.7%）.讨论需要更大规模的研究来检查NTD与种族、母亲吸烟史和感染之间的关系。NTD可作为一种生物标志物，以指导急性临床护理和识别婴儿的急性和慢性发病风险。
Background Hypothermia is related to increased morbidity and mortality in very preterm infants; continuous temperature monitoring is necessary. Thermoregulation is limited in preterm infants.Objectives The purpose of the research was to assess and describe negative temperature differential (NTD) and assess the associations of NTD with infant demographic characteristics, medical history, and clinical events.Methods An exploratory, case study design was used. Abdominal and foot temperature was measured every minute over the first 2 weeks of life in 22 preterm infants at less than 29 weeks gestational age.Results All infants experienced NTD. Daily NTD in all infants across all study days ranged from 0 to 70.7%; 2-week mean NTD over all infants ranged from 7.3% to 38.5%. Four infants treated for late onset of infection had a higher NTD than 18 infants without infection (M = 27.8%, SD = 9.52 vs. M = 16.4%, SD = 5.34, p < .05). Although not statistically significant, higher mean percentage of NTD was noted in infants having early onset infection (24.1% vs. 16.4%), African American race (20.0% vs. 15.3%), and/or being born to a mother who smoked during pregnancy (26.6% vs. 16.7%).Discussion A larger study is needed to examine associations between NTD and race, maternal smoking history, and infection. NTD might be used as a biomarker to guide acute clinical care and identify infants at risk for acute and chronic morbidity.