Lung carcinoma induction in Syrian golden hamsters by intratracheal instillation of 1,6-dinitropyrene.
Lung carcinoma induction in Syrian golden hamsters by intratracheal instillation of 1,6-dinitropyrene.
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气管内滴注 1,6-二硝基芘诱导叙利亚金仓鼠患肺癌。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
S. Sato
中科院分区：
文献类型：
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作者：
S. Takayama;T. Ishikawa;H. Nakajima;S. Sato
通过气管内滴注1，6-二硝基-1，6-吡喃(1，6-DNP)对非近交系叙利亚金黄地鼠进行致癌试验。将0.5 mg的1，6-DNP混悬于0.2毫升生理盐水气管内，每周一次，持续26周。在用1，6-DNP处理的雄性和雌性仓鼠中，分别有100%和90%的金黄地鼠在实验20-48周发生肺癌。除肺癌外，接受1，6-DNP治疗的男性和女性中均有60%发展为髓系白血病。在对照仓鼠中没有发现肿瘤。
The carcinogenicity of a potent mutagen, 1,6-dinitropyrene (1,6-DNP), was examined by intratracheal instillation into non-inbred Syrian golden hamsters of both sexes. Animals were treated with 0.5 mg of 1,6-DNP suspended in 0.2 ml of saline intratracheally once a week for 26 weeks. Lung carcinomas developed in experimental weeks 20-48 in 100 and 90%, respectively, of the male and female hamsters treated with 1,6-DNP. Besides lung carcinomas, myeloid leukemias developed in 60% of both males and females treated with 1,6-DNP. No tumors were found in control hamsters.
1-硝基芘（一种最近公认的环境诱变剂）诱导大鼠乳腺肿瘤。
影响因子：
11.2
作者：
Hirose,M;Lee,MS;Wang,CY;King,CM
通讯作者：
King,CM