Genetic Analysis of the Stereotypic Phenotype in Peromyscus maniculatus (deer mice)
Genetic Analysis of the Stereotypic Phenotype in Peromyscus maniculatus (deer mice)
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DOI：
10.1007/s10519-022-10124-9
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发表时间：
2022-11-24
影响因子：
2.6
通讯作者：
Felder，Michael R.
中科院分区：
文献类型：
--
作者：
Davis，Shannon W.;Kiaris，Hippokratis;Felder，Michael R.
Peromyscus maniculatus, including the laboratory stock BW, have been used as a model organism for autism spectrum disorder and obsessive–compulsive disorder because of the high occurrence of stereotypy. Several studies have identified neurological and environmental components of the phenotype; however, the heritability of the phenotype has not been examined. This study characterizes the incidence and heritability of vertical jumping stereotypy (VS) and backflipping (BF) behavior in the BW stock of thePeromyscusGenetic Stock Center, which are indicative of autism spectrum disorders. In addition, interspecies crosses betweenP. maniculatusandP. polionotuswere also performed to further dissect genetically stereotypic behavior. The inheritance pattern of VS suggests that multiple genes result in a quantitative trait with low VS being dominant over high VS. The inheritance pattern of BF suggests that fewer genes are involved, with one allele causing BF in a dominant fashion. An association analysis in BW could reveal the underlying genetic loci associated with stereotypy inP. maniculatus, especially for the BF behavior.
