Further evidence of relation between prenatal famine and major affective disorder
Further evidence of relation between prenatal famine and major affective disorder
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DOI：
10.1176/appi.ajp.157.2.190
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发表时间：
2000-02-01
影响因子：
17.7
通讯作者：
Susser, ES
中科院分区：
文献类型：
--
作者：
Brown, AS;van Os, J;Susser, ES
目的：在先前的一项研究中，作者证明了妊娠中期至晚期的产前饥荒与需要住院治疗的严重情感障碍之间的联系。在这项研究中，他们试图通过使用荷兰出生队列中新发现的病例来检查这种关联，这些病例以前用于检查这种关联的性别特异性，并评估这种关系是否存在于单极和双相情感障碍中。方法：作者比较了在1944-1945年荷兰饥饿冬季期间，在妊娠的每个三个月都暴露于和没有暴露于饥荒的出生队列中需要住院治疗的主要情感障碍的风险。这些需要住院治疗的严重情感障碍病例是最近从国家精神病登记处确定的。该登记研究的更大数据集用于按性别和诊断亚型进行分析。结果如下：对于新确定的病例，相对于未暴露受试者，妊娠中期暴露于饥饿的受试者发生需要住院治疗的严重情感障碍的风险增加，妊娠晚期暴露的受试者发生需要住院治疗的严重情感障碍的风险显著增加。对于整个确定期的病例，在妊娠中期和妊娠晚期暴露于饥荒的患者发生情感障碍的风险显著增加。对男性和女性以及单极和双相情感障碍的影响得到了证实。结论：这些结果为作者先前关于妊娠中晚期饥荒与情感障碍之间关系的研究结果提供了支持。
Objective: in a previous study, the authors demonstrated an association between prenatal famine in middle to late gestation and major affective disorders requiring hospitalization. In this study, they sought to examine the association by using newly identified cases from the Dutch birth cohort used previously to examine the gender specificity of the association and to assess whether this relation is present for both unipolar and bipolar affective disorders. Method: The authors compared the risk of major affective disorder requiring hospitalization in birth cohorts who were and were not exposed, in each trimester of gestation, to famine during the Dutch Hunger Winter of 1944-1945. These cases of major affective disorder requiring hospitalization were newly ascertained from a national psychiatric registry. A larger data set from this registry was used for analysis by gender and diagnostic subtype. Results: For the newly ascertained cases, the risk of developing major affective disorder requiring hospitalization was increased for subjects with exposure to famine in the second trimester and was increased significantly for subjects with exposure in the third trimester, relative to unexposed subjects. For the cases from the entire period of ascertainment, the risk of developing affective disorder was significantly increased for those exposed to famine during the second and the third trimesters of gestation. The effects were demonstrated for men and women and for unipolar and bipolar affective disorders. Conclusions: These results provide support for the authors' previous findings on the association between middle to late gestational famine and affective disorder.