Reduced midbrain-pons serotonin transporter binding in patients with obsessive-compulsive disorder
Reduced midbrain-pons serotonin transporter binding in patients with obsessive-compulsive disorder
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DOI：
10.1111/j.1600-0447.2006.00940.x
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发表时间：
2007-05-01
影响因子：
6.7
通讯作者：
Bolwig, T. G.
中科院分区：
文献类型：
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作者：
Hasselbalch, S. G.;Hansen, E. S.;Bolwig, T. G.
目的：为了评估目前的假设，强迫症（OCD）的病理生理学通过研究5-羟色胺受体结合在强迫症患者使用单光子发射计算机断层扫描（SPECT）。方法：我们研究了9例（4男5女，年龄范围21-56岁）符合DMS-III-R标准的强迫症使用SPECT和5-羟色胺转运体（SERT）示踪剂I-123-β-CIT。结果：与对照组相比，强迫症患者中脑-脑桥I-123-beta-CIT结合率降低（BP 2 0.97 +/- 0.07 vs.0.84 +/- 0.12，P = 0.011）。BP 2和任何的临床变量（发病年龄，病程，和耶鲁-布朗强迫量表评分）之间没有相关性。结论：本研究表明，减少多巴胺能输入到额皮质下电路在强迫症，从而减少抑制性调节的5-羟色胺对这些电路。
Objective: To evaluate current hypothesis regarding the pathophysiology of obsessive-compulsive disorder (OCD) by studying the serotonin receptor binding in patients with OCD using single photon emission computerized tomography (SPECT).Method: We studied nine patients (four men and five women, age range 21-56 years) fulfilling the DMS-III-R criteria for OCD using SPECT and the serotonin transporter (SERT) tracer I-123-beta-CIT. SERT binding potential (BP2) was determined by Logan plot derived from seven scans obtained during 10-400 min.Results: The binding of I-123-beta-CIT in midbrain-pons was reduced in OCD patients when compared with controls (BP2 0.97 +/- 0.07 vs. 0.84 +/- 0.12, P = 0.011). There was no correlation between BP2 and any of the clinical variables (age at onset, disease duration, and Yale-Brown Obsessive-Compulsive Scale score).Conclusion: This study suggests a reduced serotonergic input into the fronto-subcortical circuits in OCD, thereby diminishing the inhibitory regulation of serotonin on these circuits.