Genetic diversity and haplotypic structure of Chinese Kazak ethnic group revealed by 19 STRs on the X chromosome
Genetic diversity and haplotypic structure of Chinese Kazak ethnic group revealed by 19 STRs on the X chromosome
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X染色体19个STR揭示中国哈萨克族遗传多样性和单倍型结构
DOI：
10.1016/j.gene.2016.11.018
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发表时间：
2017-02-05
期刊：
影响因子：
3.5
通讯作者：
Zhu, Bo-Feng
中科院分区：
文献类型：
--
作者：
Liu, Yao-Shun;Meng, Hao-Tian;Zhu, Bo-Feng
近年来，X染色体短串联重复序列（X-STR）已广泛应用于涉及复杂亲属关系的法医实践中，并且在群体遗传学中也发挥着越来越重要的作用。为研究中国哈萨克族X染色体上19个STR位点的遗传多态性，我们在评估了中国新疆维吾尔自治区伊犁哈萨克自治州的300名（男性149名，女性151名）无关健康个体中这19个位点的等位基因频率和单倍型频率，评估了这些位点在法医学中的法医学应用价值，并比较了人群差异。哈萨克族和其他参考族之间的关系。我们在这些 X-STR 位点上总共观察到 240 个等位基因，相应的等位基因频率范围为 0.0017 至 0.5917。研究中，在DXS10135位点发现了最高的多态性。女性的综合歧视力为 0.999999999999999999999985，男性的综合歧视力为 0.999999999999968。本研究表明，19 个 X-STR 位点对于法医鉴定案件和涉及女性后代的亲属关系分析都非常有用。 (C) 2016 Elsevier B.V. 保留所有权利。
X-chromosomal short tandem repeats (X-STRs) have been widely used in forensic practices involving complicated ties of kinship over the past years, and also play an increasingly important role in population genetics. To study the genetic polymorphisms of 19 STR loci on X chromosome in Chinese Kazak ethnic group, we investigated the allelic and haplotypic frequencies of the 19 loci in 300(149 males and 151 females) unrelated healthy individuals from Ili Kazak Autonomous Prefecture, Xinjiang Uigur Autonomous Region of China after having evaluated the forensic application value of these loci in forensic sciences, and then compared the population distinctions between the Kazak group and other reference groups. We observed a total of 240 alleles at these X-STR loci with the corresponding allelic frequencies ranging from 0.0017 to 0.5917. In the study, the highest polymorphism was found at DXS10135 locus. The combined power of discrimination in females was 0.999999999999999999999985 and in males 0.999999999999968. The present study indicates that the 19 X-STR loci are very useful for both forensic identification cases and kinship analyses involving a female offspring. (C) 2016 Elsevier B.V. All rights reserved.