Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.
Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.
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DOI：
10.1136/bmjopen-2015-008808
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发表时间：
2015-08-11
期刊：
影响因子：
2.9
通讯作者：
Sattar N
中科院分区：
文献类型：
--
作者：
Morris RW;Taylor AE;Fluharty ME;Bjørngaard JH;Åsvold BO;Elvestad Gabrielsen M;Campbell A;Marioni R;Kumari M;Korhonen T;Männistö S;Marques-Vidal P;Kaakinen M;Cavadino A;Postmus I;Husemoen LL;Skaaby T;Ahluwalia TV;Treur JL;Willemsen G;Dale C;Wannamethee SG;Lahti J;Palotie A;Räikkönen K;McConnachie A;Padmanabhan S;Wong A;Dalgård C;Paternoster L;Ben-Shlomo Y;Tyrrell J;Horwood J;Fergusson DM;Kennedy MA;Nohr EA;Christiansen L;Kyvik KO;Kuh D;Watt G;Eriksson JG;Whincup PH;Vink JM;Boomsma DI;Davey Smith G;Lawlor D;Linneberg A;Ford I;Jukema JW;Power C;Hyppönen E;Jarvelin MR;Preisig M;Borodulin K;Kaprio J;Kivimaki M;Smith BH;Hayward C;Romundstad PR;Sørensen TI;Munafò MR;Sattar N
采用孟德尔随机化方法，调查吸烟过多是否与一系列区域性肥胖表型有关，特别是与腹型肥胖有关的表型。孟德尔随机Meta分析使用CHRNA5-CHRNA3-CHRNB4基因区域中的一个遗传变异(rs16969968/rs1051730)作为吸烟重的代理，对吸烟重与一系列肥胖症表型之间的关系进行荟萃分析。来自烟草和酒精因果分析研究联盟(CARTA)的29项研究的148名 731名欧洲血统的现任、前任和从不吸烟者的年龄为≥16 。腰围和臀围，以及腰臀比。数据包括多达66名 809从不吸烟者、43名 009既往吸烟者和38名 913目前每日吸烟者。在当前吸烟者中，对于每一个额外的微小等位基因，腰围的几何平均值降低了−0.40%(95%CI−0.57%至−0.22%)，对臀围、腰臀比和体重指数的影响分别为−0.31%(95%CI−0.42%至−0.19)、−0.08%(−0.19%至0.03%)和−0.74%(−0.96%至−0.51%)。相比之下，在非吸烟者中，这些影响分别高出0.23%(0.09%至0.36%)、0.17%(0.08%至0.26%)、0.07%(−0.01%至0.15%)和0.35%(0.18%至0.52%)。当调整体重指数的三个中心性肥胖指标时，当前吸烟者的影响改变了方向，腰围增加了0.14个百分点(0.05%~0.22%)，臀围增加了0.02个百分点(−0.05%~0.08%)，腰臀比增加了0.10个百分点(0.02%~0.19%)。对于给定的BMI，与吸烟增加相关的基因变异与腰围增加有关。为了控制体重而吸烟可能会导致中心性肥胖症的积累。
To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes. 148 731 current, former and never-smokers of European ancestry aged ≥16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Waist and hip circumferences, and waist-hip ratio. The data included up to 66 809 never-smokers, 43 009 former smokers and 38 913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by −0.40% (95% CI −0.57% to −0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being −0.31% (95% CI −0.42% to −0.19), −0.08% (−0.19% to 0.03%) and −0.74% (−0.96% to −0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (−0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (−0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele. For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.