Inhibitory Effects of Retinol Are Greater than Retinoic Acid on the Growth and Adhesion of Human Refractory Cancer Cells
Inhibitory Effects of Retinol Are Greater than Retinoic Acid on the Growth and Adhesion of Human Refractory Cancer Cells
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DOI：
10.1248/bpb.b15-00794
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发表时间：
2016-04-01
影响因子：
2
通讯作者：
Takahashi, Noriko
中科院分区：
文献类型：
--
作者：
Li, Chuan;Imai, Masahiko;Takahashi, Noriko
维生素A成分包括在视觉中起作用的视黄醇和已用于治疗人类急性早幼粒细胞白血病的视黄酸（RA）。然而，视黄醇（Rol）及其酯棕榈酸视黄酯（RP）对癌症的影响还不清楚。在目前的研究中，我们研究了这些药物对各种癌细胞增殖和粘附的影响。罗尔表现出剂量依赖性抑制人难治性前列腺癌细胞的增殖，而RA和RP表现出很小或没有效果。与此相反，RA抑制人乳腺癌细胞的生长在更大程度上比罗尔在低浓度，但不是在高浓度。罗尔抑制粘附难治性和前列腺癌细胞在更大程度上比RA，而它抑制乳腺癌细胞以及RA和JHP-1细胞的粘附不如RA有效。这些结果表明，Rol是癌细胞生长和粘附的有效抑制剂，这两者都与转移和肿瘤进展有关。Rol可能对癌症的临床治疗有用。
Vitamin A constituents include retinal, which plays a role in vision, and retinoic acid (RA), which has been used in the therapy of human acute promyelocytic leukemia. However, the effects on cancer of retinol (Rol) and its ester, retinyl palmitate (RP) are not known well. In the current study, we examined the effects of these agents on proliferation and adhesion of various cancer cells. Rol exhibited dose-dependent inhibition of the proliferation of human refractory and prostate cancer cells, while RA and RP showed little or no effect. In contrast, RA inhibited the growth of human breast cancer cells to a greater extent than Rol at low concentrations, but not at high concentrations. Rol suppressed adhesion of refractory and prostate cancer cells to a greater extent than RA, while it suppressed adhesion of breast cancer cells as well as RA and of JHP-1 cells less effectively than RA. These results indicate that Rol is a potent suppressor of cancer cell growth and adhesion, which are both linked to metastasis and tumor progression. Rol might be useful for the clinical treatment of cancer.