Low co-existence rates of Lactobacillus spp. and Helicobacter pylori detected in gastric biopsies from patients with gastrointestinal symptoms
Low co-existence rates of Lactobacillus spp. and Helicobacter pylori detected in gastric biopsies from patients with gastrointestinal symptoms
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DOI：
10.4321/s1130-01082012000900005
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发表时间：
2012-09-01
期刊：
影响因子：
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通讯作者：
González, Carlos L.
中科院分区：
文献类型：
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作者：
García, Apolinaria;Sáez, Katia;González, Carlos L.
背景：胃内细菌多样性包括不同种类。其中，幽门螺杆菌，一种与胃病有关的微生物，经常在这个栖息地分离出来。此外，乳杆菌属，一个包括益生菌菌株的属，也已经在这个栖息地中被记录。这两种菌在有症状患者胃中的共存性有待阐明。和H.方法：对427例有胃肠道不适症状的智利患者的胃活检（胃窦和/或胃体）进行分析。螺杆幽门螺杆菌感染和/或乳杆菌属（Lactobacillus spp.）通过标准培养技术确定每个患者的定植状态，并且还建立了这些物种的存在与年龄、性别或胃病严重程度之间的统计学相关性。和H.幽门。42.6%的患者中分离出前一种菌作为独特菌，而乳杆菌属。在19.4%的个体中分离为单一种。慢性非萎缩性胃炎以乳杆菌属为主。非定植个体，而慢性非萎缩性胃炎和慢性萎缩性胃炎的诊断在乳杆菌属中是相似的。窝藏个体（p < 0.001）。乳杆菌属的存在。结论：乳杆菌属细菌与乳杆菌属细菌之间的Pearson负相关，与性别无关。和H. pylori（r =-0.112，p = 0.020）表明在有症状患者的胃粘膜中两种菌的共存率很低。
Background: bacterial diversity of the stomach includes various species. Among them, Helicobacter pylori, a microorganism which has been associated to gastric diseases, is frequently isolated in this habitat. In addition, Lactobacillus spp., a genus including probiotic strains, has also been documented in this habitat. The co-existence of these two species in the stomach of symptomatic patient needs to be elucidated.Aims: our goal was to establish if Lactobacillus spp. and H. pylori co-exist in the stomach mucosa of symptomatic patients.Methods: gastric biopsies (antrum and/or the body) from 427 Chilean patients with gastrointestinal discomfort were analyzed. The H. pylori infection and/or Lactobacillus spp. colonization status was determined for each patient by standard culture techniques, and statistical correlations between the presence of those species and the age, gender, or the severity of the gastric disease were also established.Results: only 6.1% of the samples presented co-existence of Lactobacillus spp. and H. pylori. This former species was isolated in 42.6% of the patients as unique species, while Lactobacillus spp. was isolated as single species in 19.4% of the individuals. Chronic non-atrophic gastritis was prevalent in Lactobacillus spp. non colonized individuals, while chronic non-atrophic and chronic atrophic gastritis diagnosis was similar in Lactobacillus spp. harbouring individuals (p < 0.001). The presence of Lactobacillus spp. significantly increased with age (p = 0.005), independently of gender.Conclusion: the negative Pearson correlation between Lactobacillus spp. and H. pylori (r = -0.112, p = 0.020) indicates that the co-existence of both species is low in human gastric mucosa of symptomatic patients.