Effect of cholinergic stimulation on the distribution of amylase activity.
Effect of cholinergic stimulation on the distribution of amylase activity.
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胆碱能刺激对淀粉酶活性分布的影响。
DOI：
10.11480/btmd.300301
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
H. Momoi
中科院分区：
文献类型：
--
作者：
K. Miyasaka;H. Momoi
测定了大鼠胰腺切除后几种组织和血浆中淀粉酶的活性。胰腺切除降低了大鼠血液和几种组织中的α-淀粉酶含量，而颌下腺的淀粉酶活性没有变化。尤其是小肠内容物的淀粉酶活性下降了约99%，小肠粘膜也是如此。胆碱能刺激后，几种组织和血浆中淀粉酶活性有升高趋势，但差异无统计学意义。胆碱能刺激后，只有小肠和远端肠腔中的酶活性显著增加。但在小肠中的最大浓度仍仅为正常非胰腺切除动物的2%。这些数据表明，在这种胆碱能刺激模式下，正常大鼠血浆和几个组织中的淀粉酶活性没有显著增加，这是由于缺乏淀粉酶的潜在来源，即胰腺。
The amylase activity was measured in the several tissues and plasma after pancreatectomy in the rat. Pancreatectomy decreased the alpha-amylase content of the blood and several tissues in the rat, whereas the amylase activity did not change in the submandibular gland. Especially, the content of the small intestine lost about 99% of its amylase activity as did the small intestinal mucosa. After cholinergic stimulation, the amylase activity in several tissues and plasma tended to increase but the increase was not statistically significant. Only the enzyme activity in the lumen of the small intestine and distal intestine increased substantially after cholinergic stimulation. However, the maximal concentration in the small intestine was still only 2% of that in the normal non-pancreatectomized animal. The data suggest that the absence of the dramatic increase in the amylase activity in the plasma and several tissues that was observed in the normal rat after this pattern of cholinergic stimulation was due to the absence of the potential source of amylase, the pancreas.