Insight toward Early Diagnosis of Leprosy through Analysis of the Developing Antibody Responses of Mycobacterium leprae-Infected Armadillos
Insight toward Early Diagnosis of Leprosy through Analysis of the Developing Antibody Responses of Mycobacterium leprae-Infected Armadillos
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DOI：
10.1128/cvi.00420-10
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发表时间：
2011-02-01
影响因子：
--
通讯作者：
Reed, Steven G.
中科院分区：
文献类型：
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作者：
Duthie, Malcolm S.;Truman, Richard W.;Reed, Steven G.
麻风病是一种使人衰弱的慢性疾病，由麻风分枝杆菌感染引起。在过去20年中，世界卫生组织以确定和治疗病人为基础的预防控制战略使世界范围内登记的麻风病例数量显著减少。尽管做出了这些努力，每年发现的麻风新病例数量仍然相对稳定。麻风病感染继续构成健康问题。建议早期诊断，以加强控制方案。在这项研究中，我们已经研究了抗原特异性免疫球蛋白反应的发展与实验感染M。麻风病，以确定那些反应，发展最迅速和强大的感染后。对M.评估了麻风特异性酚糖脂I和先前证明具有诊断潜力的几种蛋白质抗原。我们的研究结果确定了几个抗原，可以提供早期诊断M。麻风感染，但也表明在抗原特异性抗体的发展中存在相当大的变异性。我们的数据表明，抗原的组合可能需要提供准确和早期的麻风病诊断。
Leprosy is a debilitating chronic disease caused by infection with Mycobacterium leprae. A World Health Organization-directed control strategy based upon the identification and treatment of patients has resulted in a marked reduction in the number of registered worldwide leprosy cases over the last 20 years. Despite these efforts, the number of new leprosy cases detected each year now remains relatively stable, and M. leprae infection continues to pose a health problem. It is suggested that earlier diagnosis is required to strengthen control programs. In this study, we have examined the development of antigen-specific immunoglobulin responses within armadillos experimentally infected with M. leprae to identify those responses that develop most rapidly and robustly following infection. Antibody responses to the M. leprae-specific phenolic glycolipid I and several protein antigens previously demonstrated to have diagnostic potential were assessed. Our results identify several antigens that can provide early diagnosis of M. leprae infection but also indicate considerable variability in the development of antigen-specific antibodies. Our data suggest that a combination of antigens is likely required to provide accurate and early leprosy diagnosis.