Multimonth Prescription of Antiretroviral Therapy Among Children and Adolescents: Experiences From the Baylor International Pediatric AIDS Initiative in 6 African Countries
Multimonth Prescription of Antiretroviral Therapy Among Children and Adolescents: Experiences From the Baylor International Pediatric AIDS Initiative in 6 African Countries
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DOI：
10.1097/qai.0000000000001730
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发表时间：
2018-08-15
影响因子：
3.6
通讯作者：
Abrams, Elaine J.
中科院分区：
文献类型：
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作者：
Kim, Maria H.;Wanless, Richard S.;Abrams, Elaine J.
背景：为了实现90-90-90目标，需要采取不同的护理方法。我们描述了在6个非洲国家的卓越中心向青年提供抗逆转录病毒治疗（ART）的多月处方（MMP）时间表的经验。我们分析了0-19岁开始接受ART治疗的患者的电子病历数据。当临床稳定[改善CD 4（+），病毒载量（VL）抑制，或最小的HIV相关发病率]和ART依从性（药丸计数95%-105%）。在间隔>56天的3次连续访视后，患者被分类为过渡到MMP。我们使用生存分析来描述死亡和失访。我们描述了使用6个月和VL抑制的CD 4（+）的依从性和可接受的免疫应答（
Background: To reach 90-90-90 targets, differentiated approaches to care are necessary. We describe the experience of delivering multimonth prescription (MMP) schedules of antiretroviral therapy (ART) to youth at centers of excellence in 6 African countries.Methods: We analyzed data from electronic medical records of patients aged 0-19 years started on ART. Patients were eligible to transition from monthly prescribing to MMP when clinically stable [improving CD4(+), viral load (VL) suppression, or minimal HIV-associated morbidity] and ART adherent (pill count 95%-105%). Patients were classified as transitioned to MMP after 3 consecutive visits at intervals of >56 days. We used survival analysis to describe death and lost to follow-up. We described adherence and acceptable immunologic response by CD4(+) using 6-month and VL suppression (