STUDIES ON MEDICINAL-PLANTS OF SRI-LANKA .14. TOXICITY OF SOME TRADITIONAL MEDICINAL HERBS
STUDIES ON MEDICINAL-PLANTS OF SRI-LANKA .14. TOXICITY OF SOME TRADITIONAL MEDICINAL HERBS
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DOI：
10.1016/0378-8741(85)90078-9
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发表时间：
1985-01-01
影响因子：
5.4
通讯作者：
PANABOKKE, RG
中科院分区：
文献类型：
--
作者：
ARSECULERATNE, SN;GUNATILAKA, AAL;PANABOKKE, RG
对斯里兰卡传统阿育吠陀药典中的药用植物 (75) 进行了化学筛选，以确定其是否含有生物碱和吡咯里西啶生物碱。其中，Crotolaria juncea L.被发现含有吡咯里西啶生物碱，其生物效应与吡咯里西啶生物碱毒性一致。用 3 种缺乏吡咯里西啶生物碱的植物（即 Aegle marmelos (L.) Corr.、Hemidesmus indicus (L.) Ait）对大鼠进行喂养试验。 F. 和 Terminalia chebula Retz。产生肝脏病变，其中包括中央静脉异常，而 T. chebula 和 Withania somnifera (L.) Dunal 产生明显的肾脏病变。
Medicinal plants (75) of the traditional Ayurvedic pharmacopoeia of Sri Lanka were screened chemically for alkaloids and pyrrolizidine alkaloids. Of these, Crotolaria juncea L. was found to contain pyrrolizidine alkaloids with biological effects consistent with pyrrolizidine alkaloid toxicity. Feeding trials in rats with 3 plants lacking pyrrolizidine alkaloids, namely Aegle marmelos (L.) Corr., Hemidesmus indicus (L.) Ait. F. and Terminalia chebula Retz. produced hepatic lesions which included central vein abnormalities while T. chebula and Withania somnifera (L.) Dunal produced marked renal lesions.