Peptide-Mediated Synthesis of Zeolitic Imidazolate Framework-8 with Controllable Morphology and Size
Peptide-Mediated Synthesis of Zeolitic Imidazolate Framework-8 with Controllable Morphology and Size
复制标题
肽介导合成具有可控形态和尺寸的沸石咪唑酯骨架-8
DOI：
10.1021/acs.langmuir.0c02496
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发表时间：
2020
期刊：
影响因子：
3.9
通讯作者：
Li Sun
中科院分区：
文献类型：
--
作者：
Jiaming Xuan;Yang Liu;Xiaomin Xu;Zhen Ding;Ziwei Zhuang;Zhang Yuxin;Yan Yunpeng;Meiwen Cao;Shengjie Wang;Yongqing Xia;Li Sun
具有Nap-lx-GPLGLAG-R4-NH 2（x = 2、4和6，简称为I2 R4、I4 R4和I6 R4）序列的肽用作在水中合成沸石咪唑酯骨架-8（ZIF-8）的封端剂。添加肽可以显著抑制ZIF-8晶体的生长。ZIF-8晶体的形状和大小与异亮氨酸（Ile，I）残基的数量以及肽的浓度密切相关。随着异亮氨酸残基数目从6个减少到2个，ZIF-8晶体的形状从菱形十二面体到截顶菱形十二面体再到立方体。在1.0mM的肽浓度下，ZIF-8晶体的形态分别为立方体、截顶菱形十二面体和典型的菱形十二面体（在I2 R4、I4 R4和I6 R4的情况下）。此外，颗粒尺寸可以从约100 μ m调节。1.7本工作发展了一种简单、绿色的方法，在水中合成了形状和尺寸可控的ZIF-8晶体，具有很高的生物医学和生物学应用潜力。
Peptides with a sequence of Nap-Ix-GPLGLAG-R4-NH2 (x = 2, 4, and 6, shorted as I2R4, I4R4, and I6R4) were used as capping agents for the synthesis of zeolitic imidazolate framework-8 (ZIF-8) in water. Peptide addition can significantly inhibit the growth of ZIF-8 crystals. The shape and size of ZIF-8 crystals was related closely to the number of isoleucine (Ile, I) residues as well as concentration of the peptide. The shape of ZIF-8 crystals changes from rhomboid dodecahedron to truncated rhombic dodecahedron to cube with the decreasing number of isoleucine residues from six to two. At a peptide concentration of 1.0 mM, the morphology of ZIF-8 crystals was cubic, truncated rhombic dodecahedron, and typical rhombic dodecahedron in the cases of I2R4, I4R4, and I6R4, respectively. Also, the particle size can be regulated from ca. 1.7 μm to <100 nm by controlling the peptide concentration from 0 to 2.0 mM. This work develops a simple and green method for the synthesis of ZIF-8 crystals with controllable shape and size in water, which shows high potential for biomedical and biological applications.