Development of the cardiac cell model by applying object-oriented methods
Development of the cardiac cell model by applying object-oriented methods
复制标题
应用面向对象方法开发心脏细胞模型
DOI：
--
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
A. Noma
中科院分区：
文献类型：
--
作者：
N. Sarai;A. Amano;S. Matsuoka;T. Matsuda;A. Noma
尽管在分子和细胞水平上积累了大量关于生物和生理活动的知识，但对各种细胞功能的定量解释仍然很困难。定量动力学模型在计算机上集成了单个分子的功能，为建立和检验生物活性机制的假说提供了有力的工具。本研究应用面向对象的方法建立细胞功能的计算模型。单元模型被描述为一个树形结构的功能模块，这些功能模块是相互独立和可交换的。心脏细胞模型由功能模块（如离子通道）和变量（如离子浓度）重建。根据生物学基础对功能模块进行了分类。开发一个通用的模拟平台将有助于开发各种各样的细胞模型。
Quantitative explanation of various cell functions is still difficult, although there is a huge amount of accumulation of knowledge about the biological and physiological activities on both the molecular and cellular levels. The quantitative dynamic model, which integrates the functions of individual molecules on the computer, may provide a powerful tool to create and test the hypotheses of the mechanisms underlying the biological activities. In this study, the object-oriented methods were applied to develop the computational model of the cell function. The cell model is described as a tree structure of the functional modules that are independent of each other and exchangeable. The cardiac cell model is reconstituted of both the functional modules such as ion channels and the variables such as ion concentrations. The functional modules were classified according to the biological bases. The development of a common simulation platform will facilitate developing a large variety of cell models.