New perspectives on the management of low levels of high-density lipoprotein cholesterol
New perspectives on the management of low levels of high-density lipoprotein cholesterol
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DOI：
10.1001/archinte.159.10.1049
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发表时间：
1999-05-24
影响因子：
--
通讯作者：
Jacobson, TA
中科院分区：
文献类型：
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作者：
Harper, CR;Jacobson, TA
血清高密度脂蛋白胆固醇（HDL-C）水平是冠心病（CHD）的有效预测因子。据估计，11%的美国男性具有孤立的低HDL-C水平，并且关于这些患者的管理存在不确定性。低HDL-C水平和CHD之间的因果关系得到流行病学、动物和人类临床研究的支持。本文就HDL-C的结构、功能及其在动脉粥样硬化防治中的作用作一综述。然后，我们提出了一种方法，孤立的低HDL-C的患者，可能是有用的初级保健医生。提出了一种用于现有CHD患者的算法，而治疗非CHD患者的决定是基于他们在Fracket心脏研究风险预测图表上的评分。
A serum high-density lipoprotein cholesterol (HDL-C) level is a potent predictor of coronary heart disease (CHD), It has been estimated that 11% of US men have isolated low HDL-C levels, and there is uncertainty regarding the management of these patients. A cause-and-effect relationship between low HDL-C levels and CHD is supported by epidemiological, animal, and human clinical studies. We reviewed the structure and function of HDL-C and its role in preventing atherosclerosis. We then suggested an approach to the patient with isolated low HDL-C that may be useful to the primary care physician. An algorithm was proposed for use in patients with existing CHD, while the decision to treat patients without CHD was based on their score on the Framingham Heart Study risk prediction chart.