Propranolol in treatment of huge and complicated infantile hemangiomas in egyptian children.
Propranolol in treatment of huge and complicated infantile hemangiomas in egyptian children.
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DOI：
10.1155/2014/541810
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发表时间：
2014
影响因子：
1.5
通讯作者：
Shreef KS
中科院分区：
文献类型：
--
作者：
Hassan BA;Shreef KS
背景婴儿血管瘤（IH）是婴儿期最常见的良性肿瘤。普萘洛尔最近被报道是一种非常有效的治疗IH。本研究的目的是评价普萘洛尔治疗复杂的IH病例的疗效和副作用。患者和方法。这项前瞻性临床研究包括30名患有巨大或复杂IH的儿童;他们的年龄范围从2个月到1岁。口服普萘洛尔治疗。对治疗结果进行临床评价。结果浅表性皮肤血管瘤开始反应普萘洛尔治疗后一到两周内开始治疗。发生完全缓解所需的平均治疗期为9.4个月。普萘洛尔治疗耐受性良好，副作用少。除1例外，停药后未观察到肿瘤反弹生长。结论普萘洛尔是一种很有前途的治疗IH的方法，没有明显的副作用。然而，需要更长随访期的进一步研究。
Background. Infantile hemangiomas (IHs) are the most common benign tumours of infancy. Propranolol has recently been reported to be a highly effective treatment for IHs. This study aimed to evaluate the efficacy and side effects of propranolol for treatment of complicated cases of IHs. Patients and Methods. This prospective clinical study included 30 children with huge or complicated IHs; their ages ranged from 2 months to 1 year. They were treated by oral propranolol. Treatment outcomes were clinically evaluated. Results. Superficial cutaneous hemangiomas began to respond to propranolol therapy within one to two weeks after the onset of treatment. The mean treatment period that was needed for the occurrence of complete resolution was 9.4 months. Treatment with propranolol was well tolerated and had few side effects. No rebound growth of the tumors was noted when propranolol dosing stopped except in one case. Conclusion. Propranolol is a promising treatment for IHs without obvious side effects. However, further studies with longer follow-up periods are needed.