Safety and Efficacy of Ketamine-Fentanyl-Dexmedetomidine-Induced Anesthesia and Analgesia in Neonatal and Aged Rats.
Safety and Efficacy of Ketamine-Fentanyl-Dexmedetomidine-Induced Anesthesia and Analgesia in Neonatal and Aged Rats.
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氯胺酮-芬太尼-右美托咪定麻醉和镇痛对新生和老年大鼠的安全性和有效性
DOI：
10.1177/15593258211063987
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Jiang H
中科院分区：
文献类型：
--
作者：
Zhou X;Li W;Wang H;Li C;Jiang H
许多麻醉方案的有效性是有争议的，特别是在脆弱的儿童和老年人群中有副作用。本研究旨在评价氯胺酮、芬太尼和右美托咪定（KFD）低剂量组合用于新生大鼠和老年大鼠麻醉和镇痛的安全性和有效性。KFD在出生后第6天（P6）或13个月（13 M）大的大鼠中迅速诱导麻醉和镇痛。同时，KFD给药对心血管和呼吸系统无不良影响。与对照组相比，KFD组大鼠的肾、肝、脑组织形态学无明显变化。此外，给药KFD对两个年龄组大鼠的肝脏和肾脏功能没有影响。对照组与补虚方组的认知功能无明显差异。这些结果表明，KFD联合给药提供了安全有效的麻醉。总的来说，我们的研究结果表明KFD组合在麻醉管理中的潜在意义。
The efficiency of many anesthetic regimens is controversial, with side effects especially in the vulnerable children and old population. The study aimed to evaluate the safety and efficacy of low-dose combination of ketamine, fentanyl, and dexmedetomidine (KFD) for anesthesia and analgesia in the neonatal and elderly rats. KFD rapidly induced anesthesia and analgesia in either postnatal days 6 (P6) or 13 months (13M) old rats. Meanwhile, KFD administration had no adverse effects on the cardiovascular and respiratory systems. Compared with control group, there were no distinct morphologic changes in kidney, liver, and brain in KFD group. Moreover, administration of KFD had no influence on hepatic and renal function in rats of both ages. Furthermore, there was no obvious difference in cognitive function between control and KFD groups. These results indicated that the administration of KFD combination offered safe and efficient anesthesia. Collectively, our results suggest the potential implication of the KFD combination in anesthesia management.
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影响因子：
168.9
作者：
Inouye, Sharon K.;Westendorp, Rudi G. J.;Saczynski, Jane S.
通讯作者：
Saczynski, Jane S.
影响因子：
2.9
作者：
Singh SA;Prakash K;Sharma S;Dhakate G;Bhatia V
通讯作者：
Bhatia V
影响因子：
8.8
作者：
Sanders, Robert D.;Xu, Jing;Maze, Mervyn
通讯作者：
Maze, Mervyn
DOI：
10.1111/pan.13359
发表时间：
2018-06
期刊：
Paediatric anaesthesia
影响因子：
--
作者：
Shi Y;Hu D;Rodgers EL;Katusic SK;Gleich SJ;Hanson AC;Schroeder DR;Flick RP;Warner DO
通讯作者：
Warner DO
DOI：
10.4103/0259-1162.143110
发表时间：
2014-09
期刊：
Anesthesia, essays and researches
影响因子：
--
作者：
Kurdi MS;Theerth KA;Deva RS
通讯作者：
Deva RS