Antimicrobial Resistance and Pharmacodynamics of Canine and Feline Pathogenic E. coli in the United States
Antimicrobial Resistance and Pharmacodynamics of Canine and Feline Pathogenic E. coli in the United States
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DOI：
10.5326/jaaha-ms-5805
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发表时间：
2012-11-01
影响因子：
1.3
通讯作者：
Hatchcock, Terri
中科院分区：
文献类型：
--
作者：
Boothe, Dawn;Smaha, Tim;Hatchcock, Terri
描述了 2005 年 5 月至 2005 年 9 月期间从奥本大学临床药理学实验室 (n = 165) 或来自美国四个地区的商业诊断实验室 ([CDL]；n = 211) 收集的犬科动物 (n = 301) 和猫科动物 (n = 75) 致病性大肠杆菌 (E. coli) 分离株的耐药百分比和最低抑制浓度 (MIC)。测试的药物包括阿莫西林 (AMX)、阿莫西林三水合物/克拉维酸钾 (AMXC)、头孢泊肟 (CFP)、多西环素 (DXY)、恩诺沙星 (ENR)、庆大霉素 (GM) 和甲氧苄啶-磺胺甲恶唑 (TMS)。尿液分离株最为常见 (n = 174)。与耳朵相比，从呼吸道、尿液和皮肤分离的菌株的耐药率最高。与西部各州相比，来自南部和中部各州的样本的耐药性也最大（P AMXC (37 +/- 2.5%) > CFP (21.8 +/- 2%) = DXY (22 +/- 2.1%) = ENR (20 +/- 2.1%) = TMS (19 +/- 2%) > GM (12 +/- 1.7%)。不同抗生素药物之间的耐药性存在显着差异（P
Percent resistance and minimum inhibitory concentrations (MIC) were described for canine (n = 301) and feline (n = 75) pathogenic Escherichia coli (E. coli) isolates solicited during May 2005 to Sep 2005 from the Clinical Pharmacology Laboratory at Auburn University (n = 165) or commercial diagnostic laboratories ([CDL]; n = 211) from four regions in the USA. Drugs tested were amoxicillin (AMX), amoxicillin trihydrate/ clavulanate potassium (AMXC), cefpodoxime (CFP), doxycycline (DXY), enrofloxacin (ENR), gentamicin (GM) and trimethoprim- sulfamethoxazole (TMS). Urinary isolates were most common (n = 174). Percent resistance was greatest for isolates from the respiratory tract, urine, and skin compared with the ear. Resistance was also greatest for samples sent from the south and central states compared with the western states (P AMXC (37 +/- 2.5%) > CFP (21.8 +/- 2%) = DXY (22 +/- 2.1%) = ENR (20 +/- 2.1%) = TMS (19 +/- 2%) > GM (12 +/- 1.7%). There was a significant difference in resistance between the different antibiotic drugs (P