Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography
Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography
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DOI：
10.3233/jad-170998
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
Villemagne, Victor L.
中科院分区：
文献类型：
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作者：
Brown, Belinda M.;Rainey-Smith, Stephanie R.;Villemagne, Victor L.
许多动物研究报告说，运动可以减少阿尔茨海默病的病理堆积，包括淀粉样β蛋白(Aβ)和tau。此外，我们之前报告了人类人群中较高水平的体力活动(PA)与较低的脑Aβ负荷之间的关系。最近出现的tau正电子发射断层扫描(PET)示踪剂使我们能够扩展我们的研究，以评估PA和脑tau负荷之间的关系。利用澳大利亚成像、生物标记物和生活方式(AIBL)研究的数据，我们研究了习惯性PA和PET量化的tau负荷之间的横截面关系。根据自我报告的PA水平，43名认知健康的老年人被分为低-中度PA(n=16)或高PA(n=27)。所有参与者都接受了AV1451示踪剂的tau PET成像。与HPA组(Z分数：-0.28+/-1.18)相比，LMPA组的新皮质tau负荷(z分数：1.22+/-1.98)显著增加。在检查颞顶皮质和前额叶皮质的区域tau负荷时，LMPA组和HPA组之间的差异也很明显。我们的结果表明，自我报告的PA水平和脑tau负荷之间存在关联。未来使用更大样本量的纵向和干预性研究对于进一步研究tau和PA之间的关系的性质是至关重要的。
Numerous animal studies have reported exercise reduces the accumulation of Alzheimer's disease pathology, including amyloid-beta (A beta) and tau. Furthermore, we previously reported a relationship between higher levels of physical activity (PA) and lower brain A beta burden in a human population. The recent advent of tau positron emission tomography (PET) tracers enables us to extend our investigations into the evaluation of the relationship between PA and brain tau burden. Utilizing data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we have examined the cross-sectional relationship between habitual PAand PET-quantified tau burden. Forty-three cognitively healthy older adults were categorized into low-moderate PA (LMPA; n = 16) or high PA (HPA; n = 27), based on self-reported PA levels. Tau PET imaging with the AV1451 tracer was conducted on all participants. The LMPA group had significantly higher neocortical tau burden (presented as a z-score; 1.22 +/- 1.98), compared to the HPA group (z-score: -0.28 +/- 1.18). The difference between the LMPA and HPA groups was also evident when examining regional tau burden in the temporoparietal cortex and the prefrontal cortex. Our results suggest an association between self-reported PA level and brain tau burden. Future longitudinal and interventional studies utilizing larger samples sizes are vital to further investigate the nature of the relationship between tau and PA.